Cargando…

A Low Geriatric Nutrition Risk Index Is Associated with Progression to Dialysis in Patients with Chronic Kidney Disease

Evaluating nutritional status is crucial to detecting malnutrition in patients with chronic kidney disease (CKD). The Geriatric Nutritional Risk Index (GNRI) has been associated with overall and cardiovascular mortality in the dialysis population. The aim of this study was to evaluate whether the GN...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuo, I-Ching, Huang, Jiun-Chi, Wu, Pei-Yu, Chen, Szu-Chia, Chang, Jer-Ming, Chen, Hung-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707700/
https://www.ncbi.nlm.nih.gov/pubmed/29120366
http://dx.doi.org/10.3390/nu9111228
_version_ 1783282490272645120
author Kuo, I-Ching
Huang, Jiun-Chi
Wu, Pei-Yu
Chen, Szu-Chia
Chang, Jer-Ming
Chen, Hung-Chun
author_facet Kuo, I-Ching
Huang, Jiun-Chi
Wu, Pei-Yu
Chen, Szu-Chia
Chang, Jer-Ming
Chen, Hung-Chun
author_sort Kuo, I-Ching
collection PubMed
description Evaluating nutritional status is crucial to detecting malnutrition in patients with chronic kidney disease (CKD). The Geriatric Nutritional Risk Index (GNRI) has been associated with overall and cardiovascular mortality in the dialysis population. The aim of this study was to evaluate whether the GNRI is associated with progression to dialysis in patients with moderate to advanced CKD. We enrolled 496 patients with stage 3–5 CKD who had received echocardiographic examinations, and categorized them according to baseline GNRI values calculated using the serum albumin level and body weight. The renal end-point was defined as the commencement of dialysis. During follow-up (mean, 25.2 ± 12.5 months; range, 3.3–50.1 months), 106 (21.4%) of the patients progressed to dialysis. The GNRI was positively correlated with the left ventricular ejection fraction (LVEF) (r = 0.111, p = 0.014), and negatively correlated with the left ventricular mass index (r = −0.116, p = 0.001), left ventricular hypertrophy (r = −0.095, p = 0.035), and LVEF < 50% (r = −0.138, p = 0.002). In multivariable Cox analysis, a low GNRI, female sex, high systolic blood pressure, high fasting glucose, and low estimated glomerular filtration rate were independently associated with progression to dialysis. A low GNRI was independently associated with progression to dialysis in our study cohort. The GNRI may be useful in predicting the risk of adverse renal outcomes in patients with CKD stages 3–5. Additional studies are needed to explore whether an improvement in GNRI delays CKD progression.
format Online
Article
Text
id pubmed-5707700
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-57077002017-12-05 A Low Geriatric Nutrition Risk Index Is Associated with Progression to Dialysis in Patients with Chronic Kidney Disease Kuo, I-Ching Huang, Jiun-Chi Wu, Pei-Yu Chen, Szu-Chia Chang, Jer-Ming Chen, Hung-Chun Nutrients Article Evaluating nutritional status is crucial to detecting malnutrition in patients with chronic kidney disease (CKD). The Geriatric Nutritional Risk Index (GNRI) has been associated with overall and cardiovascular mortality in the dialysis population. The aim of this study was to evaluate whether the GNRI is associated with progression to dialysis in patients with moderate to advanced CKD. We enrolled 496 patients with stage 3–5 CKD who had received echocardiographic examinations, and categorized them according to baseline GNRI values calculated using the serum albumin level and body weight. The renal end-point was defined as the commencement of dialysis. During follow-up (mean, 25.2 ± 12.5 months; range, 3.3–50.1 months), 106 (21.4%) of the patients progressed to dialysis. The GNRI was positively correlated with the left ventricular ejection fraction (LVEF) (r = 0.111, p = 0.014), and negatively correlated with the left ventricular mass index (r = −0.116, p = 0.001), left ventricular hypertrophy (r = −0.095, p = 0.035), and LVEF < 50% (r = −0.138, p = 0.002). In multivariable Cox analysis, a low GNRI, female sex, high systolic blood pressure, high fasting glucose, and low estimated glomerular filtration rate were independently associated with progression to dialysis. A low GNRI was independently associated with progression to dialysis in our study cohort. The GNRI may be useful in predicting the risk of adverse renal outcomes in patients with CKD stages 3–5. Additional studies are needed to explore whether an improvement in GNRI delays CKD progression. MDPI 2017-11-09 /pmc/articles/PMC5707700/ /pubmed/29120366 http://dx.doi.org/10.3390/nu9111228 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kuo, I-Ching
Huang, Jiun-Chi
Wu, Pei-Yu
Chen, Szu-Chia
Chang, Jer-Ming
Chen, Hung-Chun
A Low Geriatric Nutrition Risk Index Is Associated with Progression to Dialysis in Patients with Chronic Kidney Disease
title A Low Geriatric Nutrition Risk Index Is Associated with Progression to Dialysis in Patients with Chronic Kidney Disease
title_full A Low Geriatric Nutrition Risk Index Is Associated with Progression to Dialysis in Patients with Chronic Kidney Disease
title_fullStr A Low Geriatric Nutrition Risk Index Is Associated with Progression to Dialysis in Patients with Chronic Kidney Disease
title_full_unstemmed A Low Geriatric Nutrition Risk Index Is Associated with Progression to Dialysis in Patients with Chronic Kidney Disease
title_short A Low Geriatric Nutrition Risk Index Is Associated with Progression to Dialysis in Patients with Chronic Kidney Disease
title_sort low geriatric nutrition risk index is associated with progression to dialysis in patients with chronic kidney disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707700/
https://www.ncbi.nlm.nih.gov/pubmed/29120366
http://dx.doi.org/10.3390/nu9111228
work_keys_str_mv AT kuoiching alowgeriatricnutritionriskindexisassociatedwithprogressiontodialysisinpatientswithchronickidneydisease
AT huangjiunchi alowgeriatricnutritionriskindexisassociatedwithprogressiontodialysisinpatientswithchronickidneydisease
AT wupeiyu alowgeriatricnutritionriskindexisassociatedwithprogressiontodialysisinpatientswithchronickidneydisease
AT chenszuchia alowgeriatricnutritionriskindexisassociatedwithprogressiontodialysisinpatientswithchronickidneydisease
AT changjerming alowgeriatricnutritionriskindexisassociatedwithprogressiontodialysisinpatientswithchronickidneydisease
AT chenhungchun alowgeriatricnutritionriskindexisassociatedwithprogressiontodialysisinpatientswithchronickidneydisease
AT kuoiching lowgeriatricnutritionriskindexisassociatedwithprogressiontodialysisinpatientswithchronickidneydisease
AT huangjiunchi lowgeriatricnutritionriskindexisassociatedwithprogressiontodialysisinpatientswithchronickidneydisease
AT wupeiyu lowgeriatricnutritionriskindexisassociatedwithprogressiontodialysisinpatientswithchronickidneydisease
AT chenszuchia lowgeriatricnutritionriskindexisassociatedwithprogressiontodialysisinpatientswithchronickidneydisease
AT changjerming lowgeriatricnutritionriskindexisassociatedwithprogressiontodialysisinpatientswithchronickidneydisease
AT chenhungchun lowgeriatricnutritionriskindexisassociatedwithprogressiontodialysisinpatientswithchronickidneydisease