Cargando…

Maternal Iodine Intake and Offspring Attention-Deficit/Hyperactivity Disorder: Results from a Large Prospective Cohort Study

Current knowledge about the relationship between mild to moderately inadequate maternal iodine intake and/or supplemental iodine on child neurodevelopment is sparse. Using information from 77,164 mother-child pairs in the Norwegian Mother and Child Cohort Study, this study explored associations betw...

Descripción completa

Detalles Bibliográficos
Autores principales: Abel, Marianne Hope, Ystrom, Eivind, Caspersen, Ida Henriette, Meltzer, Helle Margrete, Aase, Heidi, Torheim, Liv Elin, Askeland, Ragna Bugge, Reichborn-Kjennerud, Ted, Brantsæter, Anne Lise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707711/
https://www.ncbi.nlm.nih.gov/pubmed/29137191
http://dx.doi.org/10.3390/nu9111239
_version_ 1783282492955951104
author Abel, Marianne Hope
Ystrom, Eivind
Caspersen, Ida Henriette
Meltzer, Helle Margrete
Aase, Heidi
Torheim, Liv Elin
Askeland, Ragna Bugge
Reichborn-Kjennerud, Ted
Brantsæter, Anne Lise
author_facet Abel, Marianne Hope
Ystrom, Eivind
Caspersen, Ida Henriette
Meltzer, Helle Margrete
Aase, Heidi
Torheim, Liv Elin
Askeland, Ragna Bugge
Reichborn-Kjennerud, Ted
Brantsæter, Anne Lise
author_sort Abel, Marianne Hope
collection PubMed
description Current knowledge about the relationship between mild to moderately inadequate maternal iodine intake and/or supplemental iodine on child neurodevelopment is sparse. Using information from 77,164 mother-child pairs in the Norwegian Mother and Child Cohort Study, this study explored associations between maternal iodine intake and child attention-deficit/hyperactivity disorder (ADHD) diagnosis, registered in the Norwegian Patient Registry and maternally-reported child ADHD symptoms at eight years of age. Pregnant women reported food and supplement intakes by questionnaire in gestational week 22. In total, 1725 children (2.2%) were diagnosed with ADHD. In non-users of supplemental iodine (53,360 mothers), we found no association between iodine intake from food and risk of child ADHD diagnosis (p = 0.89), while low iodine from food (<200 µg/day) was associated with higher child ADHD symptom scores (adjusted difference in score up to 0.08 standard deviation (SD), p < 0.001, n = 19,086). In the total sample, we found no evidence of beneficial effects of maternal use of iodine-containing supplements (n = 23,804) on child ADHD diagnosis or symptom score. Initiation of iodine supplement use in gestational weeks 0–12 was associated with an increased risk of child ADHD (both measures). In conclusion, insufficient maternal iodine intake was associated with increased child ADHD symptom scores at eight years of age, but not with ADHD diagnosis. No reduction of risk was associated with maternal iodine supplement use.
format Online
Article
Text
id pubmed-5707711
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-57077112017-12-05 Maternal Iodine Intake and Offspring Attention-Deficit/Hyperactivity Disorder: Results from a Large Prospective Cohort Study Abel, Marianne Hope Ystrom, Eivind Caspersen, Ida Henriette Meltzer, Helle Margrete Aase, Heidi Torheim, Liv Elin Askeland, Ragna Bugge Reichborn-Kjennerud, Ted Brantsæter, Anne Lise Nutrients Article Current knowledge about the relationship between mild to moderately inadequate maternal iodine intake and/or supplemental iodine on child neurodevelopment is sparse. Using information from 77,164 mother-child pairs in the Norwegian Mother and Child Cohort Study, this study explored associations between maternal iodine intake and child attention-deficit/hyperactivity disorder (ADHD) diagnosis, registered in the Norwegian Patient Registry and maternally-reported child ADHD symptoms at eight years of age. Pregnant women reported food and supplement intakes by questionnaire in gestational week 22. In total, 1725 children (2.2%) were diagnosed with ADHD. In non-users of supplemental iodine (53,360 mothers), we found no association between iodine intake from food and risk of child ADHD diagnosis (p = 0.89), while low iodine from food (<200 µg/day) was associated with higher child ADHD symptom scores (adjusted difference in score up to 0.08 standard deviation (SD), p < 0.001, n = 19,086). In the total sample, we found no evidence of beneficial effects of maternal use of iodine-containing supplements (n = 23,804) on child ADHD diagnosis or symptom score. Initiation of iodine supplement use in gestational weeks 0–12 was associated with an increased risk of child ADHD (both measures). In conclusion, insufficient maternal iodine intake was associated with increased child ADHD symptom scores at eight years of age, but not with ADHD diagnosis. No reduction of risk was associated with maternal iodine supplement use. MDPI 2017-11-13 /pmc/articles/PMC5707711/ /pubmed/29137191 http://dx.doi.org/10.3390/nu9111239 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Abel, Marianne Hope
Ystrom, Eivind
Caspersen, Ida Henriette
Meltzer, Helle Margrete
Aase, Heidi
Torheim, Liv Elin
Askeland, Ragna Bugge
Reichborn-Kjennerud, Ted
Brantsæter, Anne Lise
Maternal Iodine Intake and Offspring Attention-Deficit/Hyperactivity Disorder: Results from a Large Prospective Cohort Study
title Maternal Iodine Intake and Offspring Attention-Deficit/Hyperactivity Disorder: Results from a Large Prospective Cohort Study
title_full Maternal Iodine Intake and Offspring Attention-Deficit/Hyperactivity Disorder: Results from a Large Prospective Cohort Study
title_fullStr Maternal Iodine Intake and Offspring Attention-Deficit/Hyperactivity Disorder: Results from a Large Prospective Cohort Study
title_full_unstemmed Maternal Iodine Intake and Offspring Attention-Deficit/Hyperactivity Disorder: Results from a Large Prospective Cohort Study
title_short Maternal Iodine Intake and Offspring Attention-Deficit/Hyperactivity Disorder: Results from a Large Prospective Cohort Study
title_sort maternal iodine intake and offspring attention-deficit/hyperactivity disorder: results from a large prospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707711/
https://www.ncbi.nlm.nih.gov/pubmed/29137191
http://dx.doi.org/10.3390/nu9111239
work_keys_str_mv AT abelmariannehope maternaliodineintakeandoffspringattentiondeficithyperactivitydisorderresultsfromalargeprospectivecohortstudy
AT ystromeivind maternaliodineintakeandoffspringattentiondeficithyperactivitydisorderresultsfromalargeprospectivecohortstudy
AT caspersenidahenriette maternaliodineintakeandoffspringattentiondeficithyperactivitydisorderresultsfromalargeprospectivecohortstudy
AT meltzerhellemargrete maternaliodineintakeandoffspringattentiondeficithyperactivitydisorderresultsfromalargeprospectivecohortstudy
AT aaseheidi maternaliodineintakeandoffspringattentiondeficithyperactivitydisorderresultsfromalargeprospectivecohortstudy
AT torheimlivelin maternaliodineintakeandoffspringattentiondeficithyperactivitydisorderresultsfromalargeprospectivecohortstudy
AT askelandragnabugge maternaliodineintakeandoffspringattentiondeficithyperactivitydisorderresultsfromalargeprospectivecohortstudy
AT reichbornkjennerudted maternaliodineintakeandoffspringattentiondeficithyperactivitydisorderresultsfromalargeprospectivecohortstudy
AT brantsæterannelise maternaliodineintakeandoffspringattentiondeficithyperactivitydisorderresultsfromalargeprospectivecohortstudy