Cargando…

Effects of a Lutein and Zeaxanthin Intervention on Cognitive Function: A Randomized, Double-Masked, Placebo-Controlled Trial of Younger Healthy Adults

Background: Past studies have suggested that higher lutein (L) and zeaxanthin (Z) levels in serum and in the central nervous system (as quantified by measuring macular pigment optical density, MPOD) are related to improved cognitive function in older adults. Very few studies have addressed the issue...

Descripción completa

Detalles Bibliográficos
Autores principales: Renzi-Hammond, Lisa M., Bovier, Emily R., Fletcher, Laura M., Miller, L. Stephen, Mewborn, Catherine M., Lindbergh, Cutter A., Baxter, Jeffrey H., Hammond, Billy R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707718/
https://www.ncbi.nlm.nih.gov/pubmed/29135938
http://dx.doi.org/10.3390/nu9111246
_version_ 1783282494734336000
author Renzi-Hammond, Lisa M.
Bovier, Emily R.
Fletcher, Laura M.
Miller, L. Stephen
Mewborn, Catherine M.
Lindbergh, Cutter A.
Baxter, Jeffrey H.
Hammond, Billy R.
author_facet Renzi-Hammond, Lisa M.
Bovier, Emily R.
Fletcher, Laura M.
Miller, L. Stephen
Mewborn, Catherine M.
Lindbergh, Cutter A.
Baxter, Jeffrey H.
Hammond, Billy R.
author_sort Renzi-Hammond, Lisa M.
collection PubMed
description Background: Past studies have suggested that higher lutein (L) and zeaxanthin (Z) levels in serum and in the central nervous system (as quantified by measuring macular pigment optical density, MPOD) are related to improved cognitive function in older adults. Very few studies have addressed the issue of xanthophylls and cognitive function in younger adults, and no controlled trials have been conducted to date to determine whether or not supplementation with L + Z can change cognitive function in this population. Objective: The purpose of this study was to determine whether or not supplementation with L + Z could improve cognitive function in young (age 18–30), healthy adults. Design: A randomized, double-masked, placebo-controlled trial design was used. Fifty-one young, healthy subjects were recruited as part of a larger study on xanthophylls and cognitive function. Subjects were randomized into active supplement (n = 37) and placebo groups (n = 14). MPOD was measured psychophysically using customized heterochromatic flicker photometry. Cognitive function was measured using the CNS Vital Signs testing platform. MPOD and cognitive function were measured every four months for a full year of supplementation. Results: Supplementation increased MPOD significantly over the course of the year, vs. placebo (p < 0.001). Daily supplementation with L + Z and increases in MPOD resulted in significant improvements in spatial memory (p < 0.04), reasoning ability (p < 0.05) and complex attention (p < 0.04), above and beyond improvements due to practice effects. Conclusions: Supplementation with L + Z improves CNS xanthophyll levels and cognitive function in young, healthy adults. Magnitudes of effects are similar to previous work reporting correlations between MPOD and cognition in other populations.
format Online
Article
Text
id pubmed-5707718
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-57077182017-12-05 Effects of a Lutein and Zeaxanthin Intervention on Cognitive Function: A Randomized, Double-Masked, Placebo-Controlled Trial of Younger Healthy Adults Renzi-Hammond, Lisa M. Bovier, Emily R. Fletcher, Laura M. Miller, L. Stephen Mewborn, Catherine M. Lindbergh, Cutter A. Baxter, Jeffrey H. Hammond, Billy R. Nutrients Article Background: Past studies have suggested that higher lutein (L) and zeaxanthin (Z) levels in serum and in the central nervous system (as quantified by measuring macular pigment optical density, MPOD) are related to improved cognitive function in older adults. Very few studies have addressed the issue of xanthophylls and cognitive function in younger adults, and no controlled trials have been conducted to date to determine whether or not supplementation with L + Z can change cognitive function in this population. Objective: The purpose of this study was to determine whether or not supplementation with L + Z could improve cognitive function in young (age 18–30), healthy adults. Design: A randomized, double-masked, placebo-controlled trial design was used. Fifty-one young, healthy subjects were recruited as part of a larger study on xanthophylls and cognitive function. Subjects were randomized into active supplement (n = 37) and placebo groups (n = 14). MPOD was measured psychophysically using customized heterochromatic flicker photometry. Cognitive function was measured using the CNS Vital Signs testing platform. MPOD and cognitive function were measured every four months for a full year of supplementation. Results: Supplementation increased MPOD significantly over the course of the year, vs. placebo (p < 0.001). Daily supplementation with L + Z and increases in MPOD resulted in significant improvements in spatial memory (p < 0.04), reasoning ability (p < 0.05) and complex attention (p < 0.04), above and beyond improvements due to practice effects. Conclusions: Supplementation with L + Z improves CNS xanthophyll levels and cognitive function in young, healthy adults. Magnitudes of effects are similar to previous work reporting correlations between MPOD and cognition in other populations. MDPI 2017-11-14 /pmc/articles/PMC5707718/ /pubmed/29135938 http://dx.doi.org/10.3390/nu9111246 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Renzi-Hammond, Lisa M.
Bovier, Emily R.
Fletcher, Laura M.
Miller, L. Stephen
Mewborn, Catherine M.
Lindbergh, Cutter A.
Baxter, Jeffrey H.
Hammond, Billy R.
Effects of a Lutein and Zeaxanthin Intervention on Cognitive Function: A Randomized, Double-Masked, Placebo-Controlled Trial of Younger Healthy Adults
title Effects of a Lutein and Zeaxanthin Intervention on Cognitive Function: A Randomized, Double-Masked, Placebo-Controlled Trial of Younger Healthy Adults
title_full Effects of a Lutein and Zeaxanthin Intervention on Cognitive Function: A Randomized, Double-Masked, Placebo-Controlled Trial of Younger Healthy Adults
title_fullStr Effects of a Lutein and Zeaxanthin Intervention on Cognitive Function: A Randomized, Double-Masked, Placebo-Controlled Trial of Younger Healthy Adults
title_full_unstemmed Effects of a Lutein and Zeaxanthin Intervention on Cognitive Function: A Randomized, Double-Masked, Placebo-Controlled Trial of Younger Healthy Adults
title_short Effects of a Lutein and Zeaxanthin Intervention on Cognitive Function: A Randomized, Double-Masked, Placebo-Controlled Trial of Younger Healthy Adults
title_sort effects of a lutein and zeaxanthin intervention on cognitive function: a randomized, double-masked, placebo-controlled trial of younger healthy adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707718/
https://www.ncbi.nlm.nih.gov/pubmed/29135938
http://dx.doi.org/10.3390/nu9111246
work_keys_str_mv AT renzihammondlisam effectsofaluteinandzeaxanthininterventiononcognitivefunctionarandomizeddoublemaskedplacebocontrolledtrialofyoungerhealthyadults
AT bovieremilyr effectsofaluteinandzeaxanthininterventiononcognitivefunctionarandomizeddoublemaskedplacebocontrolledtrialofyoungerhealthyadults
AT fletcherlauram effectsofaluteinandzeaxanthininterventiononcognitivefunctionarandomizeddoublemaskedplacebocontrolledtrialofyoungerhealthyadults
AT millerlstephen effectsofaluteinandzeaxanthininterventiononcognitivefunctionarandomizeddoublemaskedplacebocontrolledtrialofyoungerhealthyadults
AT mewborncatherinem effectsofaluteinandzeaxanthininterventiononcognitivefunctionarandomizeddoublemaskedplacebocontrolledtrialofyoungerhealthyadults
AT lindberghcuttera effectsofaluteinandzeaxanthininterventiononcognitivefunctionarandomizeddoublemaskedplacebocontrolledtrialofyoungerhealthyadults
AT baxterjeffreyh effectsofaluteinandzeaxanthininterventiononcognitivefunctionarandomizeddoublemaskedplacebocontrolledtrialofyoungerhealthyadults
AT hammondbillyr effectsofaluteinandzeaxanthininterventiononcognitivefunctionarandomizeddoublemaskedplacebocontrolledtrialofyoungerhealthyadults