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Impact of High-Dose Multi-Strain Probiotic Supplementation on Neurocognitive Performance and Central Nervous System Immune Activation of HIV-1 Infected Individuals

Background: Gut microbiota has metabolic activity which influences mucosal homeostasis, local and systemic immune responses, and other anatomical systems (i.e., brain). The effects of dysbiosis are still poorly studied in Human Immunodeficiency Virus-1 (HIV-1) positive subjects and insufficient data...

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Autores principales: Ceccarelli, Giancarlo, Brenchley, Jason M., Cavallari, Eugenio Nelson, Corano Scheri, Giuseppe, Fratino, Mariangela, Pinacchio, Claudia, Schietroma, Ivan, Fard, Saeid Najafi, Scagnolari, Carolina, Mezzaroma, Ivano, Vullo, Vincenzo, d’Ettorre, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707741/
https://www.ncbi.nlm.nih.gov/pubmed/29160817
http://dx.doi.org/10.3390/nu9111269
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author Ceccarelli, Giancarlo
Brenchley, Jason M.
Cavallari, Eugenio Nelson
Corano Scheri, Giuseppe
Fratino, Mariangela
Pinacchio, Claudia
Schietroma, Ivan
Fard, Saeid Najafi
Scagnolari, Carolina
Mezzaroma, Ivano
Vullo, Vincenzo
d’Ettorre, Gabriella
author_facet Ceccarelli, Giancarlo
Brenchley, Jason M.
Cavallari, Eugenio Nelson
Corano Scheri, Giuseppe
Fratino, Mariangela
Pinacchio, Claudia
Schietroma, Ivan
Fard, Saeid Najafi
Scagnolari, Carolina
Mezzaroma, Ivano
Vullo, Vincenzo
d’Ettorre, Gabriella
author_sort Ceccarelli, Giancarlo
collection PubMed
description Background: Gut microbiota has metabolic activity which influences mucosal homeostasis, local and systemic immune responses, and other anatomical systems (i.e., brain). The effects of dysbiosis are still poorly studied in Human Immunodeficiency Virus-1 (HIV-1) positive subjects and insufficient data are available on the impairment of the gut-brain axis, despite neurocognitive disorders being commonly diagnosed in these patients. This study evaluated the impact of a probiotic supplementation strategy on intrathecal immune activation and cognitive performance in combined antiretroviral therapy (cART) treated HIV-1 infected subjects. Methods: Thirty-five HIV-1 infected individuals were included in this study. At baseline (T0) a battery of tests was administered, to evaluate neurocognitive function and a lumbar puncture was performed to determine neopterin concentration in cerebrospinal fluid (CSF), as a marker of Central Nervous System (CNS) immune activation. Subsequently, a subgroup of participants underwent a 6-month course of multi-strain probiotics supplementation; this intervention group was evaluated, after probiotic treatment, with a second lumbar puncture and with repeated neurocognitive tests. Results: At T0, all participants showed impaired results in at least one neurocognitive test and elevated neopterin concentrations in CSF. After supplementation with probiotics (T6), the interventional group presented a significant decrease in neopterin concentration and a significant improvement in several neurocognitive tests. In contrast, no significant modifications were observed in the neurocognitive performance of controls between T0 and T6. The CNS Penetration Effectiveness Score of antiretroviral therapy did not show an influence from any of the investigated variables. Conclusions: Multi-strain probiotic supplementation seems to exert a positive effect on neuroinflammation and neurocognitive impairment in HIV-1 infected subjects, but large trials are needed to support the concept that modulation of the gut microbiota can provide specific neurological benefits in these patients.
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spelling pubmed-57077412017-12-05 Impact of High-Dose Multi-Strain Probiotic Supplementation on Neurocognitive Performance and Central Nervous System Immune Activation of HIV-1 Infected Individuals Ceccarelli, Giancarlo Brenchley, Jason M. Cavallari, Eugenio Nelson Corano Scheri, Giuseppe Fratino, Mariangela Pinacchio, Claudia Schietroma, Ivan Fard, Saeid Najafi Scagnolari, Carolina Mezzaroma, Ivano Vullo, Vincenzo d’Ettorre, Gabriella Nutrients Article Background: Gut microbiota has metabolic activity which influences mucosal homeostasis, local and systemic immune responses, and other anatomical systems (i.e., brain). The effects of dysbiosis are still poorly studied in Human Immunodeficiency Virus-1 (HIV-1) positive subjects and insufficient data are available on the impairment of the gut-brain axis, despite neurocognitive disorders being commonly diagnosed in these patients. This study evaluated the impact of a probiotic supplementation strategy on intrathecal immune activation and cognitive performance in combined antiretroviral therapy (cART) treated HIV-1 infected subjects. Methods: Thirty-five HIV-1 infected individuals were included in this study. At baseline (T0) a battery of tests was administered, to evaluate neurocognitive function and a lumbar puncture was performed to determine neopterin concentration in cerebrospinal fluid (CSF), as a marker of Central Nervous System (CNS) immune activation. Subsequently, a subgroup of participants underwent a 6-month course of multi-strain probiotics supplementation; this intervention group was evaluated, after probiotic treatment, with a second lumbar puncture and with repeated neurocognitive tests. Results: At T0, all participants showed impaired results in at least one neurocognitive test and elevated neopterin concentrations in CSF. After supplementation with probiotics (T6), the interventional group presented a significant decrease in neopterin concentration and a significant improvement in several neurocognitive tests. In contrast, no significant modifications were observed in the neurocognitive performance of controls between T0 and T6. The CNS Penetration Effectiveness Score of antiretroviral therapy did not show an influence from any of the investigated variables. Conclusions: Multi-strain probiotic supplementation seems to exert a positive effect on neuroinflammation and neurocognitive impairment in HIV-1 infected subjects, but large trials are needed to support the concept that modulation of the gut microbiota can provide specific neurological benefits in these patients. MDPI 2017-11-21 /pmc/articles/PMC5707741/ /pubmed/29160817 http://dx.doi.org/10.3390/nu9111269 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ceccarelli, Giancarlo
Brenchley, Jason M.
Cavallari, Eugenio Nelson
Corano Scheri, Giuseppe
Fratino, Mariangela
Pinacchio, Claudia
Schietroma, Ivan
Fard, Saeid Najafi
Scagnolari, Carolina
Mezzaroma, Ivano
Vullo, Vincenzo
d’Ettorre, Gabriella
Impact of High-Dose Multi-Strain Probiotic Supplementation on Neurocognitive Performance and Central Nervous System Immune Activation of HIV-1 Infected Individuals
title Impact of High-Dose Multi-Strain Probiotic Supplementation on Neurocognitive Performance and Central Nervous System Immune Activation of HIV-1 Infected Individuals
title_full Impact of High-Dose Multi-Strain Probiotic Supplementation on Neurocognitive Performance and Central Nervous System Immune Activation of HIV-1 Infected Individuals
title_fullStr Impact of High-Dose Multi-Strain Probiotic Supplementation on Neurocognitive Performance and Central Nervous System Immune Activation of HIV-1 Infected Individuals
title_full_unstemmed Impact of High-Dose Multi-Strain Probiotic Supplementation on Neurocognitive Performance and Central Nervous System Immune Activation of HIV-1 Infected Individuals
title_short Impact of High-Dose Multi-Strain Probiotic Supplementation on Neurocognitive Performance and Central Nervous System Immune Activation of HIV-1 Infected Individuals
title_sort impact of high-dose multi-strain probiotic supplementation on neurocognitive performance and central nervous system immune activation of hiv-1 infected individuals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707741/
https://www.ncbi.nlm.nih.gov/pubmed/29160817
http://dx.doi.org/10.3390/nu9111269
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