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PON-SC – program for identifying steric clashes caused by amino acid substitutions

BACKGROUND: Amino acid substitutions due to DNA nucleotide replacements are frequently disease-causing because of affecting functionally important sites. If the substituting amino acid does not fit into the protein, it causes structural alterations that are often harmful. Clashes of amino acids caus...

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Detalles Bibliográficos
Autores principales: Čalyševa, Jelena, Vihinen, Mauno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707825/
https://www.ncbi.nlm.nih.gov/pubmed/29187139
http://dx.doi.org/10.1186/s12859-017-1947-7