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A chimeric haemagglutinin-based influenza split virion vaccine adjuvanted with AS03 induces protective stalk-reactive antibodies in mice

Seasonal influenza virus vaccines are generally effective at preventing disease, but need to be well matched to circulating virus strains for maximum benefit. Influenza viruses constantly undergo antigenic changes because of their high mutation rate in the immunodominant haemagglutinin (HA) head dom...

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Detalles Bibliográficos
Autores principales:	Nachbagauer, Raffael, Kinzler, David, Choi, Angela, Hirsh, Ariana, Beaulieu, Edith, Lecrenier, Nicolas, Innis, Bruce L, Palese, Peter, Mallett, Corey P, Krammer, Florian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707880/ https://www.ncbi.nlm.nih.gov/pubmed/29250436 http://dx.doi.org/10.1038/npjvaccines.2016.15

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