A therapeutic Porphyromonas gingivalis gingipain vaccine induces neutralising IgG1 antibodies that protect against experimental periodontitis

Porphyromonas gingivalis infected mice with an established P. gingivalis-specific inflammatory immune response were protected from developing alveolar bone resorption by therapeutic vaccination with a chimera (KAS2-A1) immunogen targeting the major virulence factors of the bacterium, the gingipain p...

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Detalles Bibliográficos
Autores principales: O’Brien-Simpson, Neil M, Holden, James A, Lenzo, Jason C, Tan, Yan, Brammar, Gail C, Walsh, Katrina A, Singleton, William, Orth, Rebecca K H, Slakeski, Nada, Cross, Keith J, Darby, Ivan B, Becher, Dorit, Rowe, Tony, Morelli, Adriana Baz, Hammet, Andrew, Nash, Andrew, Brown, Anna, Ma, Bing, Vingadassalom, Didier, McCluskey, Jacqueline, Kleanthous, Harold, Reynolds, Eric C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707886/
https://www.ncbi.nlm.nih.gov/pubmed/29263860
http://dx.doi.org/10.1038/npjvaccines.2016.22

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