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Intradermal immunisation using the TLR3-ligand Poly (I:C) as adjuvant induces mucosal antibody responses and protects against genital HSV-2 infection

Development of vaccines able to induce mucosal immunity in the genital and gastrointestinal tracts is a major challenge to counter sexually transmitted pathogens such as HIV-1 and HSV-2. Herein, we showed that intradermal (ID) immunisation with sub-unit vaccine antigens (i.e., HIV-1 gp140 and HSV-2...

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Detalles Bibliográficos
Autores principales:	Bardel, Emilie, Doucet-Ladeveze, Remi, Mathieu, Cyrille, Harandi, Ali M, Dubois, Bertrand, Kaiserlian, Dominique
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707913/ https://www.ncbi.nlm.nih.gov/pubmed/29263853 http://dx.doi.org/10.1038/npjvaccines.2016.10

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