JMJD6 promotes melanoma carcinogenesis through regulation of the alternative splicing of PAK1, a key MAPK signaling component

BACKGROUND: Melanoma, originated from melanocytes located on the basal membrane of the epithelial tissue, is the most aggressive form of skin cancer that accounts for 75% of skin cancer-related death. Although it is believed that BRAF mutation and the mitogen-activated protein kinase (MAPK) pathway...

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Detalles Bibliográficos
Autores principales: Liu, Xujun, Si, Wenzhe, Liu, Xinhua, He, Lin, Ren, Jie, Yang, Ziran, Yang, Jianguo, Li, Wanjin, Liu, Shumeng, Pei, Fei, Yang, Xiaohan, Sun, Luyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708181/
https://www.ncbi.nlm.nih.gov/pubmed/29187213
http://dx.doi.org/10.1186/s12943-017-0744-2

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