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An Easy‐to‐Machine Electrochemical Flow Microreactor: Efficient Synthesis of Isoindolinone and Flow Functionalization
Flow electrochemistry is an efficient methodology to generate radical intermediates. An electrochemical flow microreactor has been designed and manufactured to improve the efficiency of electrochemical flow reactions. With this device only little or no supporting electrolytes are needed, making proc...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708274/ https://www.ncbi.nlm.nih.gov/pubmed/29045019 http://dx.doi.org/10.1002/anie.201709717 |
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author | Folgueiras‐Amador, Ana A. Philipps, Kai Guilbaud, Sébastien Poelakker, Jarno Wirth, Thomas |
author_facet | Folgueiras‐Amador, Ana A. Philipps, Kai Guilbaud, Sébastien Poelakker, Jarno Wirth, Thomas |
author_sort | Folgueiras‐Amador, Ana A. |
collection | PubMed |
description | Flow electrochemistry is an efficient methodology to generate radical intermediates. An electrochemical flow microreactor has been designed and manufactured to improve the efficiency of electrochemical flow reactions. With this device only little or no supporting electrolytes are needed, making processes less costly and enabling easier purification. This is demonstrated by the facile synthesis of amidyl radicals used in intramolecular hydroaminations to produce isoindolinones. The combination with inline mass spectrometry facilitates a much easier combination of chemical steps in a single flow process. |
format | Online Article Text |
id | pubmed-5708274 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-57082742017-12-04 An Easy‐to‐Machine Electrochemical Flow Microreactor: Efficient Synthesis of Isoindolinone and Flow Functionalization Folgueiras‐Amador, Ana A. Philipps, Kai Guilbaud, Sébastien Poelakker, Jarno Wirth, Thomas Angew Chem Int Ed Engl Communications Flow electrochemistry is an efficient methodology to generate radical intermediates. An electrochemical flow microreactor has been designed and manufactured to improve the efficiency of electrochemical flow reactions. With this device only little or no supporting electrolytes are needed, making processes less costly and enabling easier purification. This is demonstrated by the facile synthesis of amidyl radicals used in intramolecular hydroaminations to produce isoindolinones. The combination with inline mass spectrometry facilitates a much easier combination of chemical steps in a single flow process. John Wiley and Sons Inc. 2017-11-02 2017-11-27 /pmc/articles/PMC5708274/ /pubmed/29045019 http://dx.doi.org/10.1002/anie.201709717 Text en © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Communications Folgueiras‐Amador, Ana A. Philipps, Kai Guilbaud, Sébastien Poelakker, Jarno Wirth, Thomas An Easy‐to‐Machine Electrochemical Flow Microreactor: Efficient Synthesis of Isoindolinone and Flow Functionalization |
title | An Easy‐to‐Machine Electrochemical Flow Microreactor: Efficient Synthesis of Isoindolinone and Flow Functionalization |
title_full | An Easy‐to‐Machine Electrochemical Flow Microreactor: Efficient Synthesis of Isoindolinone and Flow Functionalization |
title_fullStr | An Easy‐to‐Machine Electrochemical Flow Microreactor: Efficient Synthesis of Isoindolinone and Flow Functionalization |
title_full_unstemmed | An Easy‐to‐Machine Electrochemical Flow Microreactor: Efficient Synthesis of Isoindolinone and Flow Functionalization |
title_short | An Easy‐to‐Machine Electrochemical Flow Microreactor: Efficient Synthesis of Isoindolinone and Flow Functionalization |
title_sort | easy‐to‐machine electrochemical flow microreactor: efficient synthesis of isoindolinone and flow functionalization |
topic | Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708274/ https://www.ncbi.nlm.nih.gov/pubmed/29045019 http://dx.doi.org/10.1002/anie.201709717 |
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