Saccharide‐Containing Dynamic Proteoids

Dynamic proteoids are dynamic covalent analogues of proteins, which can be used as new adaptive biomaterials. We designed and synthesized a range of sugar‐containing dynamic proteoid biodynamers based on the polycondensation of different types of amino acid and dipeptide hydrazides with a biological...

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Detalles Bibliográficos
Autores principales: Liu, Yun, Stuart, Marc C. A., Witte, Martin D., Buhler, Eric, Hirsch, Anna K. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708278/
https://www.ncbi.nlm.nih.gov/pubmed/28981987
http://dx.doi.org/10.1002/chem.201703584
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author Liu, Yun
Stuart, Marc C. A.
Witte, Martin D.
Buhler, Eric
Hirsch, Anna K. H.
author_facet Liu, Yun
Stuart, Marc C. A.
Witte, Martin D.
Buhler, Eric
Hirsch, Anna K. H.
author_sort Liu, Yun
collection PubMed
description Dynamic proteoids are dynamic covalent analogues of proteins, which can be used as new adaptive biomaterials. We designed and synthesized a range of sugar‐containing dynamic proteoid biodynamers based on the polycondensation of different types of amino acid and dipeptide hydrazides with a biological aliphatic dialdehyde and a nonbiological aromatic dialdehyde. By using the saccharide‐based dialdehyde, the biocompatibility of biodynamers should be enhanced compared to previously reported biodynamers.
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spelling pubmed-57082782017-12-04 Saccharide‐Containing Dynamic Proteoids Liu, Yun Stuart, Marc C. A. Witte, Martin D. Buhler, Eric Hirsch, Anna K. H. Chemistry Communications Dynamic proteoids are dynamic covalent analogues of proteins, which can be used as new adaptive biomaterials. We designed and synthesized a range of sugar‐containing dynamic proteoid biodynamers based on the polycondensation of different types of amino acid and dipeptide hydrazides with a biological aliphatic dialdehyde and a nonbiological aromatic dialdehyde. By using the saccharide‐based dialdehyde, the biocompatibility of biodynamers should be enhanced compared to previously reported biodynamers. John Wiley and Sons Inc. 2017-10-25 2017-11-16 /pmc/articles/PMC5708278/ /pubmed/28981987 http://dx.doi.org/10.1002/chem.201703584 Text en © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Communications
Liu, Yun
Stuart, Marc C. A.
Witte, Martin D.
Buhler, Eric
Hirsch, Anna K. H.
Saccharide‐Containing Dynamic Proteoids
title Saccharide‐Containing Dynamic Proteoids
title_full Saccharide‐Containing Dynamic Proteoids
title_fullStr Saccharide‐Containing Dynamic Proteoids
title_full_unstemmed Saccharide‐Containing Dynamic Proteoids
title_short Saccharide‐Containing Dynamic Proteoids
title_sort saccharide‐containing dynamic proteoids
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708278/
https://www.ncbi.nlm.nih.gov/pubmed/28981987
http://dx.doi.org/10.1002/chem.201703584
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