Identification of new DNA i-motif binding ligands through a fluorescent intercalator displacement assay

i-Motifs are quadruplex DNA structures formed from sequences rich in cytosine and held together by intercalated, hemi-protonated cytosine–cytosine base pairs. These sequences are prevalent in gene promoter regions and may play a role in gene transcription. Targeting these structures with ligands cou...

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Detalles Bibliográficos
Autores principales: Sheng, Qiran, Neaverson, Joseph C., Mahmoud, Tasnim, Stevenson, Clare E. M., Matthews, Susan E., Waller, Zoë A. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708337/
https://www.ncbi.nlm.nih.gov/pubmed/28567459
http://dx.doi.org/10.1039/c7ob00710h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708337/
https://www.ncbi.nlm.nih.gov/pubmed/28567459
http://dx.doi.org/10.1039/c7ob00710h

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