Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex

Proteins typically carry out their biological functions as multi-protein complexes, which can significantly affect the affinity of small-molecule inhibitors. HSP70 is an important target in oncology, so to study its chemical biology and the drug discovery potential of the HSP70/BAG1 complex, we desi...

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Detalles Bibliográficos
Autores principales: Evans, Lindsay E., Jones, Keith, Cheeseman, Matthew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708526/
https://www.ncbi.nlm.nih.gov/pubmed/28439591
http://dx.doi.org/10.1039/c7cc01376k
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author Evans, Lindsay E.
Jones, Keith
Cheeseman, Matthew D.
author_facet Evans, Lindsay E.
Jones, Keith
Cheeseman, Matthew D.
author_sort Evans, Lindsay E.
collection PubMed
description Proteins typically carry out their biological functions as multi-protein complexes, which can significantly affect the affinity of small-molecule inhibitors. HSP70 is an important target in oncology, so to study its chemical biology and the drug discovery potential of the HSP70/BAG1 complex, we designed a high-affinity non-nucleotide fluorescence polarisation probe.
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spelling pubmed-57085262018-01-05 Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex Evans, Lindsay E. Jones, Keith Cheeseman, Matthew D. Chem Commun (Camb) Chemistry Proteins typically carry out their biological functions as multi-protein complexes, which can significantly affect the affinity of small-molecule inhibitors. HSP70 is an important target in oncology, so to study its chemical biology and the drug discovery potential of the HSP70/BAG1 complex, we designed a high-affinity non-nucleotide fluorescence polarisation probe. Royal Society of Chemistry 2017-05-07 2017-04-21 /pmc/articles/PMC5708526/ /pubmed/28439591 http://dx.doi.org/10.1039/c7cc01376k Text en This journal is © The Royal Society of Chemistry 2017 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
Evans, Lindsay E.
Jones, Keith
Cheeseman, Matthew D.
Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex
title Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex
title_full Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex
title_fullStr Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex
title_full_unstemmed Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex
title_short Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex
title_sort targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the hsp70/bag1 complex
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708526/
https://www.ncbi.nlm.nih.gov/pubmed/28439591
http://dx.doi.org/10.1039/c7cc01376k
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AT cheesemanmatthewd targetingsecondaryproteincomplexesindrugdiscoverystudyingthedruggabilityandchemicalbiologyofthehsp70bag1complex

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