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Increased levels of plasma total tau in adult Down syndrome
Down syndrome (DS) is the most prevalent chromosomal abnormality. Early-onset dementia with the pathology of Alzheimer’s disease (AD) frequently develops in DS. Reliable blood biomarkers are needed to support the diagnosis for dementia in DS, since positron emission tomography or cerebrospinal fluid...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708632/ https://www.ncbi.nlm.nih.gov/pubmed/29190730 http://dx.doi.org/10.1371/journal.pone.0188802 |
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author | Kasai, Takashi Tatebe, Harutsugu Kondo, Masaki Ishii, Ryotaro Ohmichi, Takuma Yeung, Wing Tung Esther Morimoto, Masafumi Chiyonobu, Tomohiro Terada, Naoto Allsop, David Nakagawa, Masanori Mizuno, Toshiki Tokuda, Takahiko |
author_facet | Kasai, Takashi Tatebe, Harutsugu Kondo, Masaki Ishii, Ryotaro Ohmichi, Takuma Yeung, Wing Tung Esther Morimoto, Masafumi Chiyonobu, Tomohiro Terada, Naoto Allsop, David Nakagawa, Masanori Mizuno, Toshiki Tokuda, Takahiko |
author_sort | Kasai, Takashi |
collection | PubMed |
description | Down syndrome (DS) is the most prevalent chromosomal abnormality. Early-onset dementia with the pathology of Alzheimer’s disease (AD) frequently develops in DS. Reliable blood biomarkers are needed to support the diagnosis for dementia in DS, since positron emission tomography or cerebrospinal fluid sampling is burdensome, particularly for patients with DS. Plasma t-tau is one of the established biomarkers for the diagnosis of AD, suggesting the potential value of t-tau as a biomarker for dementia in DS. The aim of this study was to assess and compare plasma levels of t-tau in adults with DS and in an age-matched control population. In this study, plasma levels of t-tau in 21 patients with DS and 22 control participants were measured by an ultrasensitive immunoassay technology, the single-molecule immunoarray (Simoa) method. We observed significantly increased plasma t-tau levels in the DS group (mean ± standard deviation (SD) = 0.643±0.493) compared to those in the control group (mean ± SD = 0.470±0.232): P = 0.0050. Moreover, age dependent correlation of plasma t-tau was only found in the DS group, and not in the control group. These findings suggest that elevated plasma t-tau levels reflect AD pathology and therefore have potential as an objective biomarker to detect dementia in adult DS. |
format | Online Article Text |
id | pubmed-5708632 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-57086322017-12-15 Increased levels of plasma total tau in adult Down syndrome Kasai, Takashi Tatebe, Harutsugu Kondo, Masaki Ishii, Ryotaro Ohmichi, Takuma Yeung, Wing Tung Esther Morimoto, Masafumi Chiyonobu, Tomohiro Terada, Naoto Allsop, David Nakagawa, Masanori Mizuno, Toshiki Tokuda, Takahiko PLoS One Research Article Down syndrome (DS) is the most prevalent chromosomal abnormality. Early-onset dementia with the pathology of Alzheimer’s disease (AD) frequently develops in DS. Reliable blood biomarkers are needed to support the diagnosis for dementia in DS, since positron emission tomography or cerebrospinal fluid sampling is burdensome, particularly for patients with DS. Plasma t-tau is one of the established biomarkers for the diagnosis of AD, suggesting the potential value of t-tau as a biomarker for dementia in DS. The aim of this study was to assess and compare plasma levels of t-tau in adults with DS and in an age-matched control population. In this study, plasma levels of t-tau in 21 patients with DS and 22 control participants were measured by an ultrasensitive immunoassay technology, the single-molecule immunoarray (Simoa) method. We observed significantly increased plasma t-tau levels in the DS group (mean ± standard deviation (SD) = 0.643±0.493) compared to those in the control group (mean ± SD = 0.470±0.232): P = 0.0050. Moreover, age dependent correlation of plasma t-tau was only found in the DS group, and not in the control group. These findings suggest that elevated plasma t-tau levels reflect AD pathology and therefore have potential as an objective biomarker to detect dementia in adult DS. Public Library of Science 2017-11-30 /pmc/articles/PMC5708632/ /pubmed/29190730 http://dx.doi.org/10.1371/journal.pone.0188802 Text en © 2017 Kasai et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Kasai, Takashi Tatebe, Harutsugu Kondo, Masaki Ishii, Ryotaro Ohmichi, Takuma Yeung, Wing Tung Esther Morimoto, Masafumi Chiyonobu, Tomohiro Terada, Naoto Allsop, David Nakagawa, Masanori Mizuno, Toshiki Tokuda, Takahiko Increased levels of plasma total tau in adult Down syndrome |
title | Increased levels of plasma total tau in adult Down syndrome |
title_full | Increased levels of plasma total tau in adult Down syndrome |
title_fullStr | Increased levels of plasma total tau in adult Down syndrome |
title_full_unstemmed | Increased levels of plasma total tau in adult Down syndrome |
title_short | Increased levels of plasma total tau in adult Down syndrome |
title_sort | increased levels of plasma total tau in adult down syndrome |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708632/ https://www.ncbi.nlm.nih.gov/pubmed/29190730 http://dx.doi.org/10.1371/journal.pone.0188802 |
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