Profiles of a broad spectrum of epigenetic DNA modifications in normal and malignant human cell lines: Proliferation rate is not the major factor responsible for the 5-hydroxymethyl-2′-deoxycytidine level in cultured cancerous cell lines

Active demethylation of 5-methylcytosine moiety in DNA occurs by its sequential oxidation to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxycytosine, catalysed by enzymes of the Ten-Eleven Translocation family proteins (TETs 1, 2 and 3). Here we analyzed for the first time all the intermedia...

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Detalles Bibliográficos
Autores principales: Foksinski, Marek, Zarakowska, Ewelina, Gackowski, Daniel, Skonieczna, Magdalena, Gajda, Karolina, Hudy, Dorota, Szpila, Anna, Bialkowski, Karol, Starczak, Marta, Labejszo, Anna, Czyz, Jaroslaw, Rzeszowska-Wolny, Joanna, Olinski, Ryszard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708640/
https://www.ncbi.nlm.nih.gov/pubmed/29190698
http://dx.doi.org/10.1371/journal.pone.0188856

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