Increased MMAB level in mitochondria as a novel biomarker of hepatotoxicity induced by Efavirenz

BACKGROUND: Efavirenz (EFV), a non-nucleoside reverse transcriptase inhibitor (NNRTI), has been widely used in the therapy of human immunodeficiency virus (HIV) infection. Some of its toxic effects on hepatic cells have been reported to display features of mitochondrial dysfunction through bioenerge...

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Detalles Bibliográficos
Autores principales: Tan, Zhimi, Jia, Xiaofang, Ma, Fang, Feng, Yanling, Lu, Hongzhou, Jin, Jun-O, Wu, Dage, Yin, Lin, Liu, Li, Zhang, Lijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708658/
https://www.ncbi.nlm.nih.gov/pubmed/29190729
http://dx.doi.org/10.1371/journal.pone.0188366

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