Cargando…

Relative muscle mass and the risk of incident type 2 diabetes: A cohort study

AIMS: The association between relative muscle mass (RMM) and incidence of type 2 diabetes (T2DM) is largely unknown. We examined whether RMM predicted development of T2DM in an apparently young healthy population. METHODS: This cohort study was comprised of 113,913 men and 89,854 women, free of T2DM...

Descripción completa

Detalles Bibliográficos
Autores principales: Hong, Sungwoo, Chang, Yoosoo, Jung, Hyun-Suk, Yun, Kyung Eun, Shin, Hocheol, Ryu, Seungho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708784/
https://www.ncbi.nlm.nih.gov/pubmed/29190709
http://dx.doi.org/10.1371/journal.pone.0188650
_version_ 1783282683277737984
author Hong, Sungwoo
Chang, Yoosoo
Jung, Hyun-Suk
Yun, Kyung Eun
Shin, Hocheol
Ryu, Seungho
author_facet Hong, Sungwoo
Chang, Yoosoo
Jung, Hyun-Suk
Yun, Kyung Eun
Shin, Hocheol
Ryu, Seungho
author_sort Hong, Sungwoo
collection PubMed
description AIMS: The association between relative muscle mass (RMM) and incidence of type 2 diabetes (T2DM) is largely unknown. We examined whether RMM predicted development of T2DM in an apparently young healthy population. METHODS: This cohort study was comprised of 113,913 men and 89,854 women, free of T2DM at baseline, who underwent a health checkup examination and were followed-up annually or biennially for an average of 2.9 years. We used skeletal muscle mass index (SMI) as an indicator of RMM. SMI (%) [total skeletal muscle mass (kg)/body weight (kg)×100] was estimated using a bioelectrical impedance analyzer. The study outcome was incident T2DM, defined as fasting serum glucose ≥126 mg/dL, HbA1C ≥6.5%, or use of medication for T2DM. RESULTS: During 589,098.8 person-years of follow-up, 4,264 individuals developed T2DM (incidence rate, 7.2 per 1000 person-years). Median age (range) at baseline was 39.1 years (18.1–87.1). RMM was negatively associated with incidence of T2DM in a dose-response manner. The multivariate-adjusted hazard ratios (95% CIs) for incident T2DM comparing quartiles 3, 2 and 1 of RMM to the highest quartile were 1.32 (1.14–1.52), 1.63 (1.42–1.86), and 2.21 (1.94–2.51), respectively, for males and 1.18 (0.88–1.58), 1.46 (1.11–1.91), and 1.96 (01.51–2.53) for females (P for trend <0.001; 0.011). This association was stronger in younger or premenopausal subjects. CONCLUSIONS: RMM was negatively associated with development of T2DM in a large sample of young and middle-aged Korean adults. Further research is required to determine whether preservation of muscle mass through intervention affects the risk of T2DM.
format Online
Article
Text
id pubmed-5708784
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-57087842017-12-15 Relative muscle mass and the risk of incident type 2 diabetes: A cohort study Hong, Sungwoo Chang, Yoosoo Jung, Hyun-Suk Yun, Kyung Eun Shin, Hocheol Ryu, Seungho PLoS One Research Article AIMS: The association between relative muscle mass (RMM) and incidence of type 2 diabetes (T2DM) is largely unknown. We examined whether RMM predicted development of T2DM in an apparently young healthy population. METHODS: This cohort study was comprised of 113,913 men and 89,854 women, free of T2DM at baseline, who underwent a health checkup examination and were followed-up annually or biennially for an average of 2.9 years. We used skeletal muscle mass index (SMI) as an indicator of RMM. SMI (%) [total skeletal muscle mass (kg)/body weight (kg)×100] was estimated using a bioelectrical impedance analyzer. The study outcome was incident T2DM, defined as fasting serum glucose ≥126 mg/dL, HbA1C ≥6.5%, or use of medication for T2DM. RESULTS: During 589,098.8 person-years of follow-up, 4,264 individuals developed T2DM (incidence rate, 7.2 per 1000 person-years). Median age (range) at baseline was 39.1 years (18.1–87.1). RMM was negatively associated with incidence of T2DM in a dose-response manner. The multivariate-adjusted hazard ratios (95% CIs) for incident T2DM comparing quartiles 3, 2 and 1 of RMM to the highest quartile were 1.32 (1.14–1.52), 1.63 (1.42–1.86), and 2.21 (1.94–2.51), respectively, for males and 1.18 (0.88–1.58), 1.46 (1.11–1.91), and 1.96 (01.51–2.53) for females (P for trend <0.001; 0.011). This association was stronger in younger or premenopausal subjects. CONCLUSIONS: RMM was negatively associated with development of T2DM in a large sample of young and middle-aged Korean adults. Further research is required to determine whether preservation of muscle mass through intervention affects the risk of T2DM. Public Library of Science 2017-11-30 /pmc/articles/PMC5708784/ /pubmed/29190709 http://dx.doi.org/10.1371/journal.pone.0188650 Text en © 2017 Hong et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Hong, Sungwoo
Chang, Yoosoo
Jung, Hyun-Suk
Yun, Kyung Eun
Shin, Hocheol
Ryu, Seungho
Relative muscle mass and the risk of incident type 2 diabetes: A cohort study
title Relative muscle mass and the risk of incident type 2 diabetes: A cohort study
title_full Relative muscle mass and the risk of incident type 2 diabetes: A cohort study
title_fullStr Relative muscle mass and the risk of incident type 2 diabetes: A cohort study
title_full_unstemmed Relative muscle mass and the risk of incident type 2 diabetes: A cohort study
title_short Relative muscle mass and the risk of incident type 2 diabetes: A cohort study
title_sort relative muscle mass and the risk of incident type 2 diabetes: a cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708784/
https://www.ncbi.nlm.nih.gov/pubmed/29190709
http://dx.doi.org/10.1371/journal.pone.0188650
work_keys_str_mv AT hongsungwoo relativemusclemassandtheriskofincidenttype2diabetesacohortstudy
AT changyoosoo relativemusclemassandtheriskofincidenttype2diabetesacohortstudy
AT junghyunsuk relativemusclemassandtheriskofincidenttype2diabetesacohortstudy
AT yunkyungeun relativemusclemassandtheriskofincidenttype2diabetesacohortstudy
AT shinhocheol relativemusclemassandtheriskofincidenttype2diabetesacohortstudy
AT ryuseungho relativemusclemassandtheriskofincidenttype2diabetesacohortstudy