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Engineering substrate promiscuity in halophilic alcohol dehydrogenase (HvADH2) by in silico design
An alcohol dehydrogenase from the halophilic archaeon Haloferax volcanii (HvADH2) has been engineered by rational design to broaden its substrate scope towards the conversion of a range of aromatic substrates, including flurbiprofenol, that is an intermediate of the non-steroidal anti-inflammatory d...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708825/ https://www.ncbi.nlm.nih.gov/pubmed/29190711 http://dx.doi.org/10.1371/journal.pone.0187482 |