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Improving virtual screening of G protein-coupled receptors via ligand-directed modeling

G protein-coupled receptors (GPCRs) play crucial roles in cell physiology and pathophysiology. There is increasing interest in using structural information for virtual screening (VS) of libraries and for structure-based drug design to identify novel agonist or antagonist leads. However, the sparse a...

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Detalles Bibliográficos
Autores principales:	Coudrat, Thomas, Simms, John, Christopoulos, Arthur, Wootten, Denise, Sexton, Patrick M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708846/ https://www.ncbi.nlm.nih.gov/pubmed/29131821 http://dx.doi.org/10.1371/journal.pcbi.1005819

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