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Factors influencing the virological testing of cornea donors
To assess the influence of donor, environment, and logistical factors on the results of virological testing of blood samples from cornea donors. Data from 670 consecutive cornea donors were analyzed retrospectively. Logistic regression analysis was used to assess the influence of different factors o...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708928/ https://www.ncbi.nlm.nih.gov/pubmed/29381929 http://dx.doi.org/10.1097/MD.0000000000008561 |
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author | Röck, Tobias Beck, Robert Jürgens, Stefan Bartz-Schmidt, Karl Ulrich Bramkamp, Matthias Thaler, Sebastian Röck, Daniel |
author_facet | Röck, Tobias Beck, Robert Jürgens, Stefan Bartz-Schmidt, Karl Ulrich Bramkamp, Matthias Thaler, Sebastian Röck, Daniel |
author_sort | Röck, Tobias |
collection | PubMed |
description | To assess the influence of donor, environment, and logistical factors on the results of virological testing of blood samples from cornea donors. Data from 670 consecutive cornea donors were analyzed retrospectively. Logistic regression analysis was used to assess the influence of different factors on the results of virological testing of blood samples from cornea donors. The mean annual rate of donors with serology-reactive or not evaluable result was 14.8% (99 of 670) (range 11.9%–16.9%). The cause of donor death by cancer increased the risk of serology-reactive or not evaluable result (P = .0300). Prolonged time between death and post mortem blood removal was associated with a higher rate of serology-reactive or not evaluable result (P < .0001). Mean monthly temperature including warmer months, differentiating between septic and aseptic donors, sex, and donor age had no significant impact on the results of virological testing of blood samples from cornea donors. The cause of donor death by cancer and a prolonged time between death and post mortem blood removal seem to be mainly responsible for serology-reactive or not evaluable result of blood samples from cornea donors. The percentage of discarded corneas caused by serology-reactive or not evaluable result may be reduced by shortening the period of time between death and post mortem blood removal. |
format | Online Article Text |
id | pubmed-5708928 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-57089282017-12-07 Factors influencing the virological testing of cornea donors Röck, Tobias Beck, Robert Jürgens, Stefan Bartz-Schmidt, Karl Ulrich Bramkamp, Matthias Thaler, Sebastian Röck, Daniel Medicine (Baltimore) 5800 To assess the influence of donor, environment, and logistical factors on the results of virological testing of blood samples from cornea donors. Data from 670 consecutive cornea donors were analyzed retrospectively. Logistic regression analysis was used to assess the influence of different factors on the results of virological testing of blood samples from cornea donors. The mean annual rate of donors with serology-reactive or not evaluable result was 14.8% (99 of 670) (range 11.9%–16.9%). The cause of donor death by cancer increased the risk of serology-reactive or not evaluable result (P = .0300). Prolonged time between death and post mortem blood removal was associated with a higher rate of serology-reactive or not evaluable result (P < .0001). Mean monthly temperature including warmer months, differentiating between septic and aseptic donors, sex, and donor age had no significant impact on the results of virological testing of blood samples from cornea donors. The cause of donor death by cancer and a prolonged time between death and post mortem blood removal seem to be mainly responsible for serology-reactive or not evaluable result of blood samples from cornea donors. The percentage of discarded corneas caused by serology-reactive or not evaluable result may be reduced by shortening the period of time between death and post mortem blood removal. Wolters Kluwer Health 2017-11-27 /pmc/articles/PMC5708928/ /pubmed/29381929 http://dx.doi.org/10.1097/MD.0000000000008561 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 5800 Röck, Tobias Beck, Robert Jürgens, Stefan Bartz-Schmidt, Karl Ulrich Bramkamp, Matthias Thaler, Sebastian Röck, Daniel Factors influencing the virological testing of cornea donors |
title | Factors influencing the virological testing of cornea donors |
title_full | Factors influencing the virological testing of cornea donors |
title_fullStr | Factors influencing the virological testing of cornea donors |
title_full_unstemmed | Factors influencing the virological testing of cornea donors |
title_short | Factors influencing the virological testing of cornea donors |
title_sort | factors influencing the virological testing of cornea donors |
topic | 5800 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708928/ https://www.ncbi.nlm.nih.gov/pubmed/29381929 http://dx.doi.org/10.1097/MD.0000000000008561 |
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