Rare metastasis to paranasal sinuses from triple-negative breast cancer: A case report and literature review

RATIONALE: Breast cancer, the most common form of cancer among women, rarely metastases to the head and neck region. To date, there have been only 6 similar cases in the literature, and most patients in these reports had very poor prognosis. PATIENTS CONCERNS: We report a 61-year-old female presented pain and numbness on the right side of the face 5 years after being diagnosed with triple-negative breast cancer. DIAGNOSIS: Magnetic resonance imaging (MRI) revealed a tissue mass in the sphenoid sinus. The tissue biopsy confirmed metastasis of breast cancer. INTERVENTION: The patient received initial chemotherapy and radiotherapy plus 10 cycles of maintenance chemotherapy OUTCOMES: The patient got long-term progression-free survival time. The total time to progression was 32 months. LESSONS: Although breast cancer rarely metastasizes to the head and neck region, awareness should be raised when breast cancer patients experience headache or have sinus-related symptoms. Chemotherapy and radiotherapy may be effective to treat paranasal sinus metastasis of triple-negative breast cancer, and patients may achieve long-term survival.