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Hemolytic anemia in alcoholic liver disease: Zieve syndrome: A case report and literature review

RATIONALE: Zieve syndrome, a rarely reported disease resulting from alcohol abuse, consists of a triad of symptoms: hemolytic anemia, cholestatic jaundice, and transient hyperlipidemia. It is largely under-recognized and under-reported, possibly because of unawareness of the condition by physicians....

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Autores principales: Liu, Miao-Xia, Wen, Xiao-Yu, Leung, Ying-Kit, Zheng, Yi-Jie, Jin, Mei-Shan, Jin, Qing-Long, Niu, Jun-Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708965/
https://www.ncbi.nlm.nih.gov/pubmed/29381966
http://dx.doi.org/10.1097/MD.0000000000008742
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author Liu, Miao-Xia
Wen, Xiao-Yu
Leung, Ying-Kit
Zheng, Yi-Jie
Jin, Mei-Shan
Jin, Qing-Long
Niu, Jun-Qi
author_facet Liu, Miao-Xia
Wen, Xiao-Yu
Leung, Ying-Kit
Zheng, Yi-Jie
Jin, Mei-Shan
Jin, Qing-Long
Niu, Jun-Qi
author_sort Liu, Miao-Xia
collection PubMed
description RATIONALE: Zieve syndrome, a rarely reported disease resulting from alcohol abuse, consists of a triad of symptoms: hemolytic anemia, cholestatic jaundice, and transient hyperlipidemia. It is largely under-recognized and under-reported, possibly because of unawareness of the condition by physicians. Here, we report a case of Zieve syndrome managed at the Jilin University First Bethune Hospital. PATIENT CONCERNS: A 30-year-old Chinese woman presented with a 4-month history of fatigue, yellowish discoloration of the eyes, and tea-colored urine. She had been a heavy drinker for 2 years prior to onset of the disease with an average daily alcohol intake of 60 g/d and more than 80 g/d for the previous 6 months. DIAGNOSIS: The diagnosis of Zieve syndrome was confirmed based on hemolysis and cholestatic jaundice secondary to alcoholic liver disease and heavy drinking. Bone marrow biopsy and liver biopsy both supported the diagnosis. INTERVENTIONS: We treated her with abstinence from alcohol and supportive therapy. OUTCOMES: The patient was discharged 14 days after admission with an improvement in symptoms, which continued to subside during the 2-month follow-up period. LESSONS: Doctors confronted with hemolysis in a patient with alcoholic liver disease should be aware of the under-reported Zieve syndrome. Recognition of this syndrome could help doctors avoid unnecessary invasive procedures and emphasize the importance of alcohol abstinence as the mainstay of management. Glucocorticoids may not be useful in treating hemolytic anemia in Zieve syndrome.
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spelling pubmed-57089652017-12-07 Hemolytic anemia in alcoholic liver disease: Zieve syndrome: A case report and literature review Liu, Miao-Xia Wen, Xiao-Yu Leung, Ying-Kit Zheng, Yi-Jie Jin, Mei-Shan Jin, Qing-Long Niu, Jun-Qi Medicine (Baltimore) 4500 RATIONALE: Zieve syndrome, a rarely reported disease resulting from alcohol abuse, consists of a triad of symptoms: hemolytic anemia, cholestatic jaundice, and transient hyperlipidemia. It is largely under-recognized and under-reported, possibly because of unawareness of the condition by physicians. Here, we report a case of Zieve syndrome managed at the Jilin University First Bethune Hospital. PATIENT CONCERNS: A 30-year-old Chinese woman presented with a 4-month history of fatigue, yellowish discoloration of the eyes, and tea-colored urine. She had been a heavy drinker for 2 years prior to onset of the disease with an average daily alcohol intake of 60 g/d and more than 80 g/d for the previous 6 months. DIAGNOSIS: The diagnosis of Zieve syndrome was confirmed based on hemolysis and cholestatic jaundice secondary to alcoholic liver disease and heavy drinking. Bone marrow biopsy and liver biopsy both supported the diagnosis. INTERVENTIONS: We treated her with abstinence from alcohol and supportive therapy. OUTCOMES: The patient was discharged 14 days after admission with an improvement in symptoms, which continued to subside during the 2-month follow-up period. LESSONS: Doctors confronted with hemolysis in a patient with alcoholic liver disease should be aware of the under-reported Zieve syndrome. Recognition of this syndrome could help doctors avoid unnecessary invasive procedures and emphasize the importance of alcohol abstinence as the mainstay of management. Glucocorticoids may not be useful in treating hemolytic anemia in Zieve syndrome. Wolters Kluwer Health 2017-11-27 /pmc/articles/PMC5708965/ /pubmed/29381966 http://dx.doi.org/10.1097/MD.0000000000008742 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-sa/4.0 This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0
spellingShingle 4500
Liu, Miao-Xia
Wen, Xiao-Yu
Leung, Ying-Kit
Zheng, Yi-Jie
Jin, Mei-Shan
Jin, Qing-Long
Niu, Jun-Qi
Hemolytic anemia in alcoholic liver disease: Zieve syndrome: A case report and literature review
title Hemolytic anemia in alcoholic liver disease: Zieve syndrome: A case report and literature review
title_full Hemolytic anemia in alcoholic liver disease: Zieve syndrome: A case report and literature review
title_fullStr Hemolytic anemia in alcoholic liver disease: Zieve syndrome: A case report and literature review
title_full_unstemmed Hemolytic anemia in alcoholic liver disease: Zieve syndrome: A case report and literature review
title_short Hemolytic anemia in alcoholic liver disease: Zieve syndrome: A case report and literature review
title_sort hemolytic anemia in alcoholic liver disease: zieve syndrome: a case report and literature review
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708965/
https://www.ncbi.nlm.nih.gov/pubmed/29381966
http://dx.doi.org/10.1097/MD.0000000000008742
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