Multiple primary cancer in the female genital system: Two rare case reports and a literature review

RATIONALE: Multiple primary cancer (MPC) refers to tumors that occur in one or multiple organs within the same patient at the same time or at different periods. MPC often occurs in the head and neck, but is rarely reported in the female genital system. PATIENT CONCERNS: In the present study, we report 2 rare cases that presented with tangible lower abdominal tumors. DIAGNOSES: Laboratory tests, pelvic ultrasound (US), computed tomography (CT), and fast histopathological examinations during surgery indicated a diagnosis of MPC. INTERVENTIONS: The 2 patients all received radical resections of multiple tumors. Outcomes: Postsurgical histopathological and immunohistochemical examinations further confirmed primary endometrial cancer and right ovarian cancer in Case 1, and primary cervical cancer and left ovarian cancer of Case 2. The 2 patients all recovered well without obvious complications. LESSONS: Our study demonstrated that female genital MPC should be noted for patients with multiple genital tumors. In addition, accurately diagnosis and radical surgical treatment should be well performed.