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Significant associations between driver gene mutations and DNA methylation alterations across many cancer types
Recent evidence shows that mutations in several driver genes can cause aberrant methylation patterns, a hallmark of cancer. In light of these findings, we hypothesized that the landscapes of tumor genomes and epigenomes are tightly interconnected. We measured this relationship using principal compon...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709060/ https://www.ncbi.nlm.nih.gov/pubmed/29125844 http://dx.doi.org/10.1371/journal.pcbi.1005840 |