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Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms

Nearly one-third of patients with acute myeloid leukemia have FMS-like tyrosine kinase 3 mutations and thus have poor survival prospects. Receptor tyrosine kinase anexelekto is critical for FMS-like tyrosine kinase 3 signaling and participates in FMS-like tyrosine kinase 3 inhibitor resistance mecha...

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Detalles Bibliográficos
Autores principales:	Ruvolo, Peter P., Ma, Huaxian, Ruvolo, Vivian R., Zhang, Xiaorui, Mu, Hong, Schober, Wendy, Hernandez, Ivonne, Gallardo, Miguel, Khoury, Joseph D., Cortes, Jorge, Andreeff, Michael, Post, Sean M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ferrata Storti Foundation 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709104/ https://www.ncbi.nlm.nih.gov/pubmed/28912176 http://dx.doi.org/10.3324/haematol.2017.168856

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