The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum

ABSTRACT: Four new phenolic amides, 4-O-methylgrossamide (1), (E)-2-(4,5-dihydroxy-2-{3-[(4-hydroxyphenethyl)amino]-3-oxopropyl}-phenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenethyl)acryl-amide (2), (Z)-lyciumamide C (3), (Z)-thoreliamide B (4), together with thirteen known phenolic amides we...

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Detalles Bibliográficos
Autores principales: Zhu, Pei-Feng, Dai, Zhi, Wang, Bei, Wei, Xin, Yu, Hao-Fei, Yan, Zi-Ru, Zhao, Xu-Dong, Liu, Ya-Ping, Luo, Xiao-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709248/
https://www.ncbi.nlm.nih.gov/pubmed/28589416
http://dx.doi.org/10.1007/s13659-017-0134-x
Descripción
Sumario:ABSTRACT: Four new phenolic amides, 4-O-methylgrossamide (1), (E)-2-(4,5-dihydroxy-2-{3-[(4-hydroxyphenethyl)amino]-3-oxopropyl}-phenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenethyl)acryl-amide (2), (Z)-lyciumamide C (3), (Z)-thoreliamide B (4), together with thirteen known phenolic amides were identified from the stem of Lycium barbarum. The structures of the new compounds were determined by spectroscopic methods. All compounds were evaluated for their anti-cancer activities against human glioma stem cell lines. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-017-0134-x) contains supplementary material, which is available to authorized users.

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