The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum

ABSTRACT: Four new phenolic amides, 4-O-methylgrossamide (1), (E)-2-(4,5-dihydroxy-2-{3-[(4-hydroxyphenethyl)amino]-3-oxopropyl}-phenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenethyl)acryl-amide (2), (Z)-lyciumamide C (3), (Z)-thoreliamide B (4), together with thirteen known phenolic amides we...

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Autores principales: Zhu, Pei-Feng, Dai, Zhi, Wang, Bei, Wei, Xin, Yu, Hao-Fei, Yan, Zi-Ru, Zhao, Xu-Dong, Liu, Ya-Ping, Luo, Xiao-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709248/
https://www.ncbi.nlm.nih.gov/pubmed/28589416
http://dx.doi.org/10.1007/s13659-017-0134-x
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author Zhu, Pei-Feng
Dai, Zhi
Wang, Bei
Wei, Xin
Yu, Hao-Fei
Yan, Zi-Ru
Zhao, Xu-Dong
Liu, Ya-Ping
Luo, Xiao-Dong
author_facet Zhu, Pei-Feng
Dai, Zhi
Wang, Bei
Wei, Xin
Yu, Hao-Fei
Yan, Zi-Ru
Zhao, Xu-Dong
Liu, Ya-Ping
Luo, Xiao-Dong
author_sort Zhu, Pei-Feng
collection PubMed
description ABSTRACT: Four new phenolic amides, 4-O-methylgrossamide (1), (E)-2-(4,5-dihydroxy-2-{3-[(4-hydroxyphenethyl)amino]-3-oxopropyl}-phenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenethyl)acryl-amide (2), (Z)-lyciumamide C (3), (Z)-thoreliamide B (4), together with thirteen known phenolic amides were identified from the stem of Lycium barbarum. The structures of the new compounds were determined by spectroscopic methods. All compounds were evaluated for their anti-cancer activities against human glioma stem cell lines. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-017-0134-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-57092482017-12-06 The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum Zhu, Pei-Feng Dai, Zhi Wang, Bei Wei, Xin Yu, Hao-Fei Yan, Zi-Ru Zhao, Xu-Dong Liu, Ya-Ping Luo, Xiao-Dong Nat Prod Bioprospect Original Article ABSTRACT: Four new phenolic amides, 4-O-methylgrossamide (1), (E)-2-(4,5-dihydroxy-2-{3-[(4-hydroxyphenethyl)amino]-3-oxopropyl}-phenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenethyl)acryl-amide (2), (Z)-lyciumamide C (3), (Z)-thoreliamide B (4), together with thirteen known phenolic amides were identified from the stem of Lycium barbarum. The structures of the new compounds were determined by spectroscopic methods. All compounds were evaluated for their anti-cancer activities against human glioma stem cell lines. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-017-0134-x) contains supplementary material, which is available to authorized users. Springer Singapore 2017-06-06 /pmc/articles/PMC5709248/ /pubmed/28589416 http://dx.doi.org/10.1007/s13659-017-0134-x Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Zhu, Pei-Feng
Dai, Zhi
Wang, Bei
Wei, Xin
Yu, Hao-Fei
Yan, Zi-Ru
Zhao, Xu-Dong
Liu, Ya-Ping
Luo, Xiao-Dong
The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum
title The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum
title_full The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum
title_fullStr The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum
title_full_unstemmed The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum
title_short The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum
title_sort anticancer activities phenolic amides from the stem of lycium barbarum
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709248/
https://www.ncbi.nlm.nih.gov/pubmed/28589416
http://dx.doi.org/10.1007/s13659-017-0134-x
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