Cargando…

BET inhibitors RVX-208 and PFI-1 reactivate HIV-1 from latency

Persistent latent reservoir in resting CD4+ T cells is a major obstacle in curing HIV-1 infection. Effective strategies for eradication of the HIV-1 reservoir are urgently needed. We report here for the first time that two BET inhibitors, RVX-208, which has entered phase II clinical trials for diver...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Panpan, Shen, Yinzhong, Yang, He, Wang, Yanan, Jiang, Zhengtao, Yang, Xinyi, Zhong, Yangcheng, Pan, Hanyu, Xu, Jianqing, Lu, Hongzhou, Zhu, Huanzhang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709369/ https://www.ncbi.nlm.nih.gov/pubmed/29192216 http://dx.doi.org/10.1038/s41598-017-16816-1

Ejemplares similares

RVX 208
Publicado: (2012)

The bromodomain and extraterminal domain inhibitor bromosporine synergistically reactivates latent HIV-1 in latently infected cells
por: Pan, Hanyu, et al.
Publicado: (2017)

PEBP1 suppresses HIV transcription and induces latency by inactivating MAPK/NF‐κB signaling
por: Yang, Xinyi, et al.
Publicado: (2020)

The BET inhibitor OTX015 reactivates latent HIV-1 through P-TEFb
por: Lu, Panpan, et al.
Publicado: (2016)

RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist
por: McLure, Kevin G., et al.
Publicado: (2013)

Zinc-Finger Nucleases Induced by HIV-1 Tat Excise HIV-1 from the Host Genome in Infected and Latently Infected Cells
por: Ji, Haiyan, et al.
Publicado: (2018)

Reactivation of HIV-1 from Latency by an Ingenol Derivative from Euphorbia Kansui
por: Wang, Pengfei, et al.
Publicado: (2017)

Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism
por: Tsujikawa, Laura M., et al.
Publicado: (2019)

Downregulation of the Complement Cascade In Vitro, in Mice and in Patients with Cardiovascular Disease by the BET Protein Inhibitor Apabetalone (RVX-208)
por: Wasiak, Sylwia, et al.
Publicado: (2017)

More Insights into the Association between RVX-208 and Pulmonary Arterial Hypertension
por: Ning, Dong, et al.
Publicado: (2020)

FKBP3 Induces Human Immunodeficiency Virus Type 1 Latency by Recruiting Histone Deacetylase 1/2 to the Viral Long Terminal Repeat
por: Yang, Xinyi, et al.
Publicado: (2021)

BET protein inhibitor apabetalone (RVX-208) suppresses pro-inflammatory hyper-activation of monocytes from patients with cardiovascular disease and type 2 diabetes
por: Wasiak, Sylwia, et al.
Publicado: (2020)

HIV-1-Specific CAR-T Cells With Cell-Intrinsic PD-1 Checkpoint Blockade Enhance Anti-HIV Efficacy in vivo
por: Jiang, Zhengtao, et al.
Publicado: (2021)

Specific and Stable Suppression of HIV Provirus Expression In Vitro by Chimeric Zinc Finger DNA Methyltransferase 1
por: Deng, Junxiao, et al.
Publicado: (2017)

Reply to Ning et al.: More Insights into the Association between RVX-208 and Pulmonary Arterial Hypertension
por: Provencher, Steeve, et al.
Publicado: (2020)

Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance specific cytotoxic activity against HIV Env(+) cells invivo
por: Pan, Hanyu, et al.
Publicado: (2023)

Prophage encoding toxin/antitoxin system PfiT/PfiA inhibits Pf4 production in Pseudomonas aeruginosa
por: Li, Yangmei, et al.
Publicado: (2020)

Selective inhibition mechanism of RVX-208 to the second bromodomain of bromo and extraterminal proteins: insight from microsecond molecular dynamics simulations
por: Wang, Qianqian, et al.
Publicado: (2017)

Data on gene and protein expression changes induced by apabetalone (RVX-208) in ex vivo treated human whole blood and primary hepatocytes
por: Wasiak, Sylwia, et al.
Publicado: (2016)

Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro
por: Gilham, Dean, et al.
Publicado: (2021)

EK-16A liposomes enhance HIV replication in ACH2 or J-Lat 10.6 cell engrafted NSG mice
por: Lu, Panpan, et al.
Publicado: (2022)

Scopoletin Reactivates Latent HIV-1 by Inducing NF-κB Expression without Global T Cell Activation
por: Zhu, Yuqi, et al.
Publicado: (2023)

Chemokine Receptor CCR2b Enhanced Anti-tumor Function of Chimeric Antigen Receptor T Cells Targeting Mesothelin in a Non-small-cell Lung Carcinoma Model
por: Wang, Yanan, et al.
Publicado: (2021)

Pandemic (H1N1) 2009, Shanghai, China
por: Shen, Yinzhong, et al.
Publicado: (2010)

Are BET Inhibitors yet Promising Latency-Reversing Agents for HIV-1 Reactivation in AIDS Therapy?
por: Salahong, Thanarat, et al.
Publicado: (2021)

A new BET on the control of HIV latency
por: Karn, Jonathan
Publicado: (2013)

TSC1 and DEPDC5 regulate HIV-1 latency through the mTOR signaling pathway
por: Jin, Shan, et al.
Publicado: (2018)

APABETALONE (RVX-208) REDUCES ACE2 PROTEIN ABUNDANCE AND PREVENTS SARS-COV-2 SPIKE PROTEIN BINDING TO HUMAN LUNG CELLS, A MOA THAT COULD ATTENUATE VIRAL ENTRY
por: Fu, Li, et al.
Publicado: (2021)

PFI-3 induces vasorelaxation with potency to reduce extracellular calcium influx in rat mesenteric artery
por: Li, Jing, et al.
Publicado: (2023)

PFI1785w: A highly conserved protein associated with pregnancy associated malaria
por: Kamaliddin, Claire, et al.
Publicado: (2017)

Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice
por: Antoch, Marina P., et al.
Publicado: (2017)

The neutralization of B.1.617.1 and B.1.1.529 sera from convalescent patients and BBIBP-CorV vaccines
por: Yang, Xinyi, et al.
Publicado: (2022)

A Novel Matrix Protein, PfY2, Functions as a Crucial Macromolecule during Shell Formation
por: Yan, Yi, et al.
Publicado: (2017)

Targeting the Non-catalytic RVxF Site of Protein Phosphatase-1 With Small Molecules for Ebola Virus Inhibition
por: Lin, Xionghao, et al.
Publicado: (2019)

FBXO34 promotes latent HIV-1 activation by post-transcriptional modulation
por: Yang, Xinyi, et al.
Publicado: (2022)

Small Molecules Targeted to a Non-Catalytic “RVxF” Binding Site of Protein Phosphatase-1 Inhibit HIV-1
por: Ammosova, Tatiana, et al.
Publicado: (2012)

Probing Effect of Papirindustriens Forskningsinstitut (PFI) Refining on Aggregation Structure of Cellulose: Crystal Packing and Hydrogen-Bonding Network
por: Li, Kunpeng, et al.
Publicado: (2020)

BET-Inhibitors Disrupt Rad21-Dependent Conformational Control of KSHV Latency
por: Chen, Horng-Shen, et al.
Publicado: (2017)

A molecular mechanism for probabilistic bet hedging and its role in viral latency
por: Chaturvedi, Sonali, et al.
Publicado: (2020)

BET bromodomain inhibitors PFI-1 and JQ1 are identified in an epigenetic compound screen to enhance C9ORF72 gene expression and shown to ameliorate C9ORF72-associated pathological and behavioral abnormalities in a C9ALS/FTD model
por: Quezada, Esteban, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_i0354r7oo5t4r9shu2e3qb3ofj