Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor

Retinitis pigmentosa results in blindness due to degeneration of photoreceptors, but spares other retinal cells, leading to the hope that expression of light-activated signaling proteins in the surviving cells could restore vision. We used a retinal G protein-coupled receptor, mGluR2, which we chemi...

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Detalles Bibliográficos
Autores principales: Berry, Michael H., Holt, Amy, Levitz, Joshua, Broichhagen, Johannes, Gaub, Benjamin M., Visel, Meike, Stanley, Cherise, Aghi, Krishan, Kim, Yang Joon, Cao, Kevin, Kramer, Richard H., Trauner, Dirk, Flannery, John, Isacoff, Ehud Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709376/
https://www.ncbi.nlm.nih.gov/pubmed/29192252
http://dx.doi.org/10.1038/s41467-017-01990-7

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