Autonomous feedback loop of RUNX1-p53-CBFB in acute myeloid leukemia cells

Although runt-related transcription factor 1 (RUNX1) and its associating core binding factor-β (CBFB) play pivotal roles in leukemogenesis, and inhibition of RUNX1 has now been widely recognized as a novel strategy for anti-leukemic therapies, it has been elusive how leukemic cells could acquire the...

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Detalles Bibliográficos
Autores principales: Morita, Ken, Noura, Mina, Tokushige, Chieko, Maeda, Shintaro, Kiyose, Hiroki, Kashiwazaki, Gengo, Taniguchi, Junichi, Bando, Toshikazu, Yoshida, Kenichi, Ozaki, Toshifumi, Matsuo, Hidemasa, Ogawa, Seishi, Liu, Pu Paul, Nakahata, Tatsutoshi, Sugiyama, Hiroshi, Adachi, Souichi, Kamikubo, Yasuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709397/
https://www.ncbi.nlm.nih.gov/pubmed/29192243
http://dx.doi.org/10.1038/s41598-017-16799-z

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