JPH203, a selective L-type amino acid transporter 1 inhibitor, induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells

Most normal cells express L-type amino acid transporter 2 (LAT2). However, L-type amino acid transporter 1 (LAT1) is highly expressed in many tumor cells and presumed to support their increased growth and proliferation. This study examined the effects of JPH203, a selective LAT1 inhibitor, on cell g...

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Detalles Bibliográficos
Autores principales: Choi, Dae Woo, Kim, Do Kyung, Kanai, Yoshikatsu, Wempe, Michael F., Endou, Hitoshi, Kim, Jong-Keun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709476/
https://www.ncbi.nlm.nih.gov/pubmed/29200902
http://dx.doi.org/10.4196/kjpp.2017.21.6.599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709476/
https://www.ncbi.nlm.nih.gov/pubmed/29200902
http://dx.doi.org/10.4196/kjpp.2017.21.6.599

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