MPTP-induced vulnerability of dopamine neurons in A53T α-synuclein overexpressed mice with the potential involvement of DJ-1 downregulation

Familial Parkinson's disease (PD) has been linked to point mutations and duplication of the α-synuclein (α-syn) gene. Mutant α-syn expression increases the vulnerability of neurons to exogenous insults. In this study, we developed a new PD model in the transgenic mice expressing mutant hemizygo...

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Detalles Bibliográficos
Autores principales: Lee, Seongmi, Oh, Seung Tack, Jeong, Ha Jin, Pak, Sok Cheon, Park, Hi-Joon, Kim, Jongpil, Cho, Hyun-seok, Jeon, Songhee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709479/
https://www.ncbi.nlm.nih.gov/pubmed/29200905
http://dx.doi.org/10.4196/kjpp.2017.21.6.625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709479/
https://www.ncbi.nlm.nih.gov/pubmed/29200905
http://dx.doi.org/10.4196/kjpp.2017.21.6.625

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