Cargando…

MPTP-induced vulnerability of dopamine neurons in A53T α-synuclein overexpressed mice with the potential involvement of DJ-1 downregulation

Familial Parkinson's disease (PD) has been linked to point mutations and duplication of the α-synuclein (α-syn) gene. Mutant α-syn expression increases the vulnerability of neurons to exogenous insults. In this study, we developed a new PD model in the transgenic mice expressing mutant hemizygo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Seongmi, Oh, Seung Tack, Jeong, Ha Jin, Pak, Sok Cheon, Park, Hi-Joon, Kim, Jongpil, Cho, Hyun-seok, Jeon, Songhee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Physiological Society and The Korean Society of Pharmacology 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709479/ https://www.ncbi.nlm.nih.gov/pubmed/29200905 http://dx.doi.org/10.4196/kjpp.2017.21.6.625

Ejemplares similares

Gami–Chunggan Formula Prevents Motor Dysfunction in MPTP/p-Induced and A53T α-Synuclein Overexpressed Parkinson’s Disease Mouse Model Though DJ-1 and BDNF Expression
por: Ahn, Sora, et al.
Publicado: (2019)

Decursin induces apoptosis in glioblastoma cells, but not in glial cells via a mitochondria-related caspase pathway
por: Oh, Seung Tack, et al.
Publicado: (2019)

Targeted Overexpression of α-Synuclein by rAAV2/1 Vectors Induces Progressive Nigrostriatal Degeneration and Increases Vulnerability to MPTP in Mouse
por: Song, Lian-Kun, et al.
Publicado: (2015)

Striatal Dopamine Transmission Is Subtly Modified in Human A53Tα-Synuclein Overexpressing Mice
por: Platt, Nicola J., et al.
Publicado: (2012)

β-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from MPTP-induced death in the absence of other synucleins
por: Ninkina, Natalia, et al.
Publicado: (2021)

A53T-Alpha-Synuclein Overexpression Impairs Dopamine Signaling and Striatal Synaptic Plasticity in Old Mice
por: Kurz, Alexander, et al.
Publicado: (2010)

Genetic deletion of vesicular glutamate transporter in dopamine neurons increases vulnerability to MPTP-induced neurotoxicity in mice
por: Shen, Hui, et al.
Publicado: (2018)

The effects of Sutaehwan-Gami on menopausal symptoms induced by ovariectomy in rats
por: Kim, Dong-Il, et al.
Publicado: (2012)

DJ-1 Acts as a Scavenger of α-Synuclein Oligomers and Restores Monomeric Glycated α-Synuclein
por: Atieh, Tamr B., et al.
Publicado: (2021)

α-Synuclein overexpression increases dopamine toxicity in BE(2)-M17 cells
por: Bisaglia, Marco, et al.
Publicado: (2010)

Pgc-1α Overexpression Downregulates Pitx3 and Increases Susceptibility to MPTP Toxicity Associated with Decreased Bdnf
por: Clark, Joanne, et al.
Publicado: (2012)

PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein
por: Ciron, Carine, et al.
Publicado: (2015)

α-Synuclein-induced dysregulation of neuronal activity contributes to murine dopamine neuron vulnerability
por: Dagra, Abeer, et al.
Publicado: (2021)

Partially oxidized DJ-1 inhibits α-synuclein nucleation and remodels mature α-synuclein fibrils in vitro
por: Kumar, Roshan, et al.
Publicado: (2019)

Plasmalogen Augmentation Reverses Striatal Dopamine Loss in MPTP Mice
por: Miville-Godbout, Edith, et al.
Publicado: (2016)

Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D(3 )receptor
por: Joyce, Jeffrey N, et al.
Publicado: (2004)

A Physical Interaction between the Dopamine Transporter and DJ-1 Facilitates Increased Dopamine Reuptake
por: Luk, Beryl, et al.
Publicado: (2015)

α-Synuclein and DJ-1 as Potential Biological Fluid Biomarkers for Parkinson’s Disease
por: Waragai, Masaaki, et al.
Publicado: (2010)

DJ-1 Inhibits α-Synuclein Aggregation by Regulating Chaperone-Mediated Autophagy
por: Xu, Chuan-Ying, et al.
Publicado: (2017)

Resistance to MPTP-Neurotoxicity in α-Synuclein Knockout Mice Is Complemented by Human α-Synuclein and Associated with Increased β-Synuclein and Akt Activation
por: Thomas, Bobby, et al.
Publicado: (2011)

Mfn2 Overexpression Attenuates MPTP Neurotoxicity In Vivo
por: Zhao, Fanpeng, et al.
Publicado: (2021)

A Comprehensive Phenotype of Non-motor Impairments and Distribution of Alpha-Synuclein Deposition in Parkinsonism-Induced Mice by a Combination Injection of MPTP and Probenecid
por: Han, Na-Ra, et al.
Publicado: (2021)

Correction: Resistance to MPTP-Neurotoxicity in α-Synuclein Knockout Mice Is Complemented by Human α-Synuclein and Associated with Increased β-Synuclein and Akt Activation
por: Thomas, Bobby, et al.
Publicado: (2012)

Alteration in brain-derived neurotrophic factor (BDNF) after treatment of mice with herbal mixture containing Euphoria longana, Houttuynia cordata and Dioscorea japonica
por: Jeon, Songhee, et al.
Publicado: (2014)

Phosphorylation of Tau and α-Synuclein Induced Neurodegeneration in MPTP Mouse Model of Parkinson’s Disease
por: Hu, Shanshan, et al.
Publicado: (2020)

Synuclein Proteins in MPTP-Induced Death of Substantia Nigra Pars Compacta Dopaminergic Neurons
por: Goloborshcheva, Valeria V., et al.
Publicado: (2022)

Novel analgesic effects of melanin-concentrating hormone on persistent neuropathic and inflammatory pain in mice
por: Jang, Jae-Hwan, et al.
Publicado: (2018)

Neuroimaging Analysis of the Dopamine Basis for Apathetic Behaviors in an MPTP-Lesioned Primate Model
por: Tian, LinLin, et al.
Publicado: (2015)

Metabolism of Dopamine in Nucleus Accumbens Astrocytes Is Preserved in Aged Mice Exposed to MPTP
por: Winner, Brittany M., et al.
Publicado: (2017)

DJ-1 Is a Redox-Dependent Molecular Chaperone That Inhibits α-Synuclein Aggregate Formation
por: Shendelman, Shoshana, et al.
Publicado: (2004)

DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease
por: Zondler, L, et al.
Publicado: (2014)

The Effects of Serping1 siRNA in α-Synuclein Regulation in MPTP-Induced Parkinson’s Disease
por: Seo, Min Hyung, et al.
Publicado: (2023)

Amygdalo‐nigral circuit mediates stress‐induced vulnerability to the parkinsonian toxin MPTP
por: Cai, Hongwei, et al.
Publicado: (2023)

Dopamine Transporter Binding Is Unaffected by L-DOPA Administration in Normal and MPTP-Treated Monkeys
por: Fernagut, Pierre-Olivier, et al.
Publicado: (2010)

Increased DJ-1 and α-Synuclein in Plasma Neural-Derived Exosomes as Potential Markers for Parkinson’s Disease
por: Zhao, Zhen-Hua, et al.
Publicado: (2019)

Srpk3 Decrease Associated with Alpha-Synuclein Increase in Muscles of MPTP-Induced Parkinson’s Disease Mice
por: Seo, Min Hyung, et al.
Publicado: (2021)

Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson’s disease
por: Duce, James A., et al.
Publicado: (2017)

Effect of rs3910105 in the Synuclein Gene on Dopamine Transporter Availability in Healthy Subjects
por: Seo, Youngduk, et al.
Publicado: (2018)

A Molotov cocktail: dopamine and α-synuclein
por: Tuma, Rabiya
Publicado: (2002)

Modulation of Alpha-Synuclein Aggregation by Dopamine Analogs
por: Latawiec, Diane, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_fm7r8r479hqdrr1sk6qh21t7vb