Prolonged Hypocalcemia Following a Single Dose of Denosumab for Diffuse Bone Metastasis of Gastric Cancer after Total Gastrectomy

Hypocalcemia is a significant adverse effect of denosumab. We herein report a case of prolonged hypocalcemia in a patient with multiple risk factors for hypocalcemia, including gastrectomy, increased bone turnover, and a poor performance status. Hypocalcemia developed after denosumab treatment for d...

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Autores principales: Iizumi, Sakura, Shimoi, Tatsunori, Nishikawa, Tadaaki, Kitano, Atsuko, Sasada, Shinsuke, Shimomura, Akihiko, Noguchi, Emi, Yunokawa, Mayu, Yonemori, Kan, Shimizu, Chikako, Fujiwara, Yasuhiro, Tamura, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709630/
https://www.ncbi.nlm.nih.gov/pubmed/28943574
http://dx.doi.org/10.2169/internalmedicine.8908-17
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author Iizumi, Sakura
Shimoi, Tatsunori
Nishikawa, Tadaaki
Kitano, Atsuko
Sasada, Shinsuke
Shimomura, Akihiko
Noguchi, Emi
Yunokawa, Mayu
Yonemori, Kan
Shimizu, Chikako
Fujiwara, Yasuhiro
Tamura, Kenji
author_facet Iizumi, Sakura
Shimoi, Tatsunori
Nishikawa, Tadaaki
Kitano, Atsuko
Sasada, Shinsuke
Shimomura, Akihiko
Noguchi, Emi
Yunokawa, Mayu
Yonemori, Kan
Shimizu, Chikako
Fujiwara, Yasuhiro
Tamura, Kenji
author_sort Iizumi, Sakura
collection PubMed
description Hypocalcemia is a significant adverse effect of denosumab. We herein report a case of prolonged hypocalcemia in a patient with multiple risk factors for hypocalcemia, including gastrectomy, increased bone turnover, and a poor performance status. Hypocalcemia developed after denosumab treatment for diffuse bone metastasis of gastric cancer, despite oral supplementation with vitamin D and calcium. To avoid serious prolonged hypocalcemia, a thorough assessment of the bone calcium metabolism is required before initiating denosumab treatment.
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spelling pubmed-57096302017-12-04 Prolonged Hypocalcemia Following a Single Dose of Denosumab for Diffuse Bone Metastasis of Gastric Cancer after Total Gastrectomy Iizumi, Sakura Shimoi, Tatsunori Nishikawa, Tadaaki Kitano, Atsuko Sasada, Shinsuke Shimomura, Akihiko Noguchi, Emi Yunokawa, Mayu Yonemori, Kan Shimizu, Chikako Fujiwara, Yasuhiro Tamura, Kenji Intern Med Case Report Hypocalcemia is a significant adverse effect of denosumab. We herein report a case of prolonged hypocalcemia in a patient with multiple risk factors for hypocalcemia, including gastrectomy, increased bone turnover, and a poor performance status. Hypocalcemia developed after denosumab treatment for diffuse bone metastasis of gastric cancer, despite oral supplementation with vitamin D and calcium. To avoid serious prolonged hypocalcemia, a thorough assessment of the bone calcium metabolism is required before initiating denosumab treatment. The Japanese Society of Internal Medicine 2017-09-25 2017-11-01 /pmc/articles/PMC5709630/ /pubmed/28943574 http://dx.doi.org/10.2169/internalmedicine.8908-17 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Iizumi, Sakura
Shimoi, Tatsunori
Nishikawa, Tadaaki
Kitano, Atsuko
Sasada, Shinsuke
Shimomura, Akihiko
Noguchi, Emi
Yunokawa, Mayu
Yonemori, Kan
Shimizu, Chikako
Fujiwara, Yasuhiro
Tamura, Kenji
Prolonged Hypocalcemia Following a Single Dose of Denosumab for Diffuse Bone Metastasis of Gastric Cancer after Total Gastrectomy
title Prolonged Hypocalcemia Following a Single Dose of Denosumab for Diffuse Bone Metastasis of Gastric Cancer after Total Gastrectomy
title_full Prolonged Hypocalcemia Following a Single Dose of Denosumab for Diffuse Bone Metastasis of Gastric Cancer after Total Gastrectomy
title_fullStr Prolonged Hypocalcemia Following a Single Dose of Denosumab for Diffuse Bone Metastasis of Gastric Cancer after Total Gastrectomy
title_full_unstemmed Prolonged Hypocalcemia Following a Single Dose of Denosumab for Diffuse Bone Metastasis of Gastric Cancer after Total Gastrectomy
title_short Prolonged Hypocalcemia Following a Single Dose of Denosumab for Diffuse Bone Metastasis of Gastric Cancer after Total Gastrectomy
title_sort prolonged hypocalcemia following a single dose of denosumab for diffuse bone metastasis of gastric cancer after total gastrectomy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709630/
https://www.ncbi.nlm.nih.gov/pubmed/28943574
http://dx.doi.org/10.2169/internalmedicine.8908-17
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