Deep Ulcers in the Ileum Associated with Mycophenolate Mofetil

A 54-year-old man was treated with mycophenolate mofetil (MMF) after undergoing living donor renal transplantation. Two years later, he experienced repeated episodes of diarrhea, and his C-reactive protein (CRP) level was found to be 12.63 mg/dL. Ileocolonoscopy showed multiple deep, punched-out ulc...

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Detalles Bibliográficos
Autores principales: Sonoda, Akira, Wada, Kurato, Mizukami, Kazuhiro, Fukuda, Kensuke, Shuto, Mitsutaka, Okamoto, Kazuhisa, Ogawa, Ryo, Okimoto, Tadayoshi, Murakami, Kazunari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709631/
https://www.ncbi.nlm.nih.gov/pubmed/28943566
http://dx.doi.org/10.2169/internalmedicine.8815-17
Descripción
Sumario:A 54-year-old man was treated with mycophenolate mofetil (MMF) after undergoing living donor renal transplantation. Two years later, he experienced repeated episodes of diarrhea, and his C-reactive protein (CRP) level was found to be 12.63 mg/dL. Ileocolonoscopy showed multiple deep, punched-out ulcers that were similar to Behçet's disease (BD) and cytomegalovirus (CMV) in the ileum. CMV infection was suspected. However, anti-cytomegalovirus agents were ineffective. The patient was subsequently diagnosed with gastrointestinal toxicity of MMF and MMF was switched to mizoribine. His symptoms improved immediately, and his CRP level normalized. Six months later, the patient's mucosa was healed.

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