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Afatinib Therapy for Brain Metastases Aggravated by a Reduction in the Dose of Erlotinib Due to the Development of Hepatotoxicity

We report an 80-year-old woman with EGFR-mutant lung adenocarcinoma with multiple brain metastases (BMs). All lesions including BM showed a successful resolution after initiating daily 150 mg erlotinib. However, a grade 2 bilirubin-increase developed, and it was necessary to reduce the dose of erlot...

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Detalles Bibliográficos
Autores principales:	Yamanaka, Yumie, Sekine, Akimasa, Kato, Terufumi, Yamakawa, Hideaki, Ikeda, Satoshi, Baba, Tomohisa, Iwasawa, Tae, Okudela, Koji, Ogura, Takashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Japanese Society of Internal Medicine 2017
Materias:	Case Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709634/ https://www.ncbi.nlm.nih.gov/pubmed/28943548 http://dx.doi.org/10.2169/internalmedicine.8638-16

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