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DPP-4 inhibition with linagliptin ameliorates the progression of premature aging in klotho−/− mice

BACKGROUND: The potential of anti-aging effect of DPP-4 inhibitors is unknown. This study was performed to determine whether linagliptin, a DPP-4 inhibitor, could protect against premature aging in klotho−/− mice. METHODS: Klotho−/− mice exhibit multiple phenotypes resembling human premature aging,...

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Detalles Bibliográficos
Autores principales:	Hasegawa, Yu, Hayashi, Kenyu, Takemoto, Yushin, Cheng, Cao, Takane, Koki, Lin, Bowen, Komohara, Yoshihiro, Kim-Mitsuyama, Shokei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709858/ https://www.ncbi.nlm.nih.gov/pubmed/29195509 http://dx.doi.org/10.1186/s12933-017-0639-y

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