Cargando…
A Simplified Overview of World Health Organization Classification Update of Central Nervous System Tumors 2016
After 8 years, an update of central nervous system (CNS) tumors was published in 2016 after 2007. First time ever, molecular markers along with histology have been used in classification of any tumor. Major changes are seen in glioma and medulloblastoma groups. Few entities have been added such as d...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709890/ https://www.ncbi.nlm.nih.gov/pubmed/29204027 http://dx.doi.org/10.4103/jnrp.jnrp_168_17 |
_version_ | 1783282865078796288 |
---|---|
author | Gupta, Anshu Dwivedi, Tanima |
author_facet | Gupta, Anshu Dwivedi, Tanima |
author_sort | Gupta, Anshu |
collection | PubMed |
description | After 8 years, an update of central nervous system (CNS) tumors was published in 2016 after 2007. First time ever, molecular markers along with histology have been used in classification of any tumor. Major changes are seen in glioma and medulloblastoma groups. Few entities have been added such as diffuse midline glioma, H3 K27M-mutant, RELA fusion-positive ependymoma, embryonal tumor with multilayered rosettes, C19MC-altered, and hybrid nerve sheath tumors. Few variants and patterns that no longer have diagnostic and/or biological relevance and have been deleted such as glioblastoma cerebri, protoplasmic and fibrillary astrocytoma, and cellular ependymoma. Other changes include deletion of term “primitive neuroectodermal tumor,” addition of criterion of brain invasion in atypical meningioma, separation of melanotic schwannoma from other schwannoma, and combination of solitary fibrous tumors and hemangiopericytoma as one entity. There is also expansion of entities in nerve sheath tumors and hematopoietic/lymphoid tumors of the CNS. In this review article, we tried to review CNS tumors 2016 classification update in a simplified manner; comparing the differences between 2016 and 2007 CNS tumors classifications with brief description of important molecular markers and finally utility as well as challenges of this classification. |
format | Online Article Text |
id | pubmed-5709890 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-57098902017-12-04 A Simplified Overview of World Health Organization Classification Update of Central Nervous System Tumors 2016 Gupta, Anshu Dwivedi, Tanima J Neurosci Rural Pract Review Article After 8 years, an update of central nervous system (CNS) tumors was published in 2016 after 2007. First time ever, molecular markers along with histology have been used in classification of any tumor. Major changes are seen in glioma and medulloblastoma groups. Few entities have been added such as diffuse midline glioma, H3 K27M-mutant, RELA fusion-positive ependymoma, embryonal tumor with multilayered rosettes, C19MC-altered, and hybrid nerve sheath tumors. Few variants and patterns that no longer have diagnostic and/or biological relevance and have been deleted such as glioblastoma cerebri, protoplasmic and fibrillary astrocytoma, and cellular ependymoma. Other changes include deletion of term “primitive neuroectodermal tumor,” addition of criterion of brain invasion in atypical meningioma, separation of melanotic schwannoma from other schwannoma, and combination of solitary fibrous tumors and hemangiopericytoma as one entity. There is also expansion of entities in nerve sheath tumors and hematopoietic/lymphoid tumors of the CNS. In this review article, we tried to review CNS tumors 2016 classification update in a simplified manner; comparing the differences between 2016 and 2007 CNS tumors classifications with brief description of important molecular markers and finally utility as well as challenges of this classification. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5709890/ /pubmed/29204027 http://dx.doi.org/10.4103/jnrp.jnrp_168_17 Text en Copyright: © 2017 Journal of Neurosciences in Rural Practice http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Gupta, Anshu Dwivedi, Tanima A Simplified Overview of World Health Organization Classification Update of Central Nervous System Tumors 2016 |
title | A Simplified Overview of World Health Organization Classification Update of Central Nervous System Tumors 2016 |
title_full | A Simplified Overview of World Health Organization Classification Update of Central Nervous System Tumors 2016 |
title_fullStr | A Simplified Overview of World Health Organization Classification Update of Central Nervous System Tumors 2016 |
title_full_unstemmed | A Simplified Overview of World Health Organization Classification Update of Central Nervous System Tumors 2016 |
title_short | A Simplified Overview of World Health Organization Classification Update of Central Nervous System Tumors 2016 |
title_sort | simplified overview of world health organization classification update of central nervous system tumors 2016 |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709890/ https://www.ncbi.nlm.nih.gov/pubmed/29204027 http://dx.doi.org/10.4103/jnrp.jnrp_168_17 |
work_keys_str_mv | AT guptaanshu asimplifiedoverviewofworldhealthorganizationclassificationupdateofcentralnervoussystemtumors2016 AT dwiveditanima asimplifiedoverviewofworldhealthorganizationclassificationupdateofcentralnervoussystemtumors2016 AT guptaanshu simplifiedoverviewofworldhealthorganizationclassificationupdateofcentralnervoussystemtumors2016 AT dwiveditanima simplifiedoverviewofworldhealthorganizationclassificationupdateofcentralnervoussystemtumors2016 |