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Cerebrovascular pathology in Down syndrome and Alzheimer disease
People with Down syndrome (DS) are at high risk for developing Alzheimer disease (AD) with age. Typically, by age 40 years, most people with DS have sufficient neuropathology for an AD diagnosis. Interestingly, atherosclerosis and hypertension are atypical in DS with age, suggesting the lack of thes...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709935/ https://www.ncbi.nlm.nih.gov/pubmed/29195510 http://dx.doi.org/10.1186/s40478-017-0499-4 |
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author | Head, Elizabeth Phelan, Michael J. Doran, Eric Kim, Ronald C. Poon, Wayne W. Schmitt, Frederick A. Lott, Ira T. |
author_facet | Head, Elizabeth Phelan, Michael J. Doran, Eric Kim, Ronald C. Poon, Wayne W. Schmitt, Frederick A. Lott, Ira T. |
author_sort | Head, Elizabeth |
collection | PubMed |
description | People with Down syndrome (DS) are at high risk for developing Alzheimer disease (AD) with age. Typically, by age 40 years, most people with DS have sufficient neuropathology for an AD diagnosis. Interestingly, atherosclerosis and hypertension are atypical in DS with age, suggesting the lack of these vascular risk factors may be associated with reduced cerebrovascular pathology. However, because the extra copy of APP leads to increased beta-amyloid peptide (Aβ) accumulation in DS, we hypothesized that there would be more extensive and widespread cerebral amyloid angiopathy (CAA) with age in DS relative to sporadic AD. To test this hypothesis CAA, atherosclerosis and arteriolosclerosis were used as measures of cerebrovascular pathology and compared in post mortem tissue from individuals with DS (n = 32), sporadic AD (n = 80) and controls (n = 37). CAA was observed with significantly higher frequencies in brains of individuals with DS compared to sporadic AD and controls. Atherosclerosis and arteriolosclerosis were rare in the cases with DS. CAA in DS may be a target for future interventional clinical trials. |
format | Online Article Text |
id | pubmed-5709935 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-57099352017-12-06 Cerebrovascular pathology in Down syndrome and Alzheimer disease Head, Elizabeth Phelan, Michael J. Doran, Eric Kim, Ronald C. Poon, Wayne W. Schmitt, Frederick A. Lott, Ira T. Acta Neuropathol Commun Research People with Down syndrome (DS) are at high risk for developing Alzheimer disease (AD) with age. Typically, by age 40 years, most people with DS have sufficient neuropathology for an AD diagnosis. Interestingly, atherosclerosis and hypertension are atypical in DS with age, suggesting the lack of these vascular risk factors may be associated with reduced cerebrovascular pathology. However, because the extra copy of APP leads to increased beta-amyloid peptide (Aβ) accumulation in DS, we hypothesized that there would be more extensive and widespread cerebral amyloid angiopathy (CAA) with age in DS relative to sporadic AD. To test this hypothesis CAA, atherosclerosis and arteriolosclerosis were used as measures of cerebrovascular pathology and compared in post mortem tissue from individuals with DS (n = 32), sporadic AD (n = 80) and controls (n = 37). CAA was observed with significantly higher frequencies in brains of individuals with DS compared to sporadic AD and controls. Atherosclerosis and arteriolosclerosis were rare in the cases with DS. CAA in DS may be a target for future interventional clinical trials. BioMed Central 2017-12-01 /pmc/articles/PMC5709935/ /pubmed/29195510 http://dx.doi.org/10.1186/s40478-017-0499-4 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Head, Elizabeth Phelan, Michael J. Doran, Eric Kim, Ronald C. Poon, Wayne W. Schmitt, Frederick A. Lott, Ira T. Cerebrovascular pathology in Down syndrome and Alzheimer disease |
title | Cerebrovascular pathology in Down syndrome and Alzheimer disease |
title_full | Cerebrovascular pathology in Down syndrome and Alzheimer disease |
title_fullStr | Cerebrovascular pathology in Down syndrome and Alzheimer disease |
title_full_unstemmed | Cerebrovascular pathology in Down syndrome and Alzheimer disease |
title_short | Cerebrovascular pathology in Down syndrome and Alzheimer disease |
title_sort | cerebrovascular pathology in down syndrome and alzheimer disease |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709935/ https://www.ncbi.nlm.nih.gov/pubmed/29195510 http://dx.doi.org/10.1186/s40478-017-0499-4 |
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