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Uveitis–Glaucoma–Hyphaema Syndrome. General review
Uveitis-Glaucoma-Hyphaema Syndrome (UGH syndrome, or “Ellingson” Syndrome) is a rare condition caused by the mechanical trauma of an intraocular lens malpositioned over adjacent structures (iris, ciliary body, iridocorneal angle), leading to a spectrum of iris transillumination defects, microhyphaem...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Romanian Society of Ophthalmology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710046/ https://www.ncbi.nlm.nih.gov/pubmed/29450365 |
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author | Zemba, Mihail Camburu, Georgiana |
author_facet | Zemba, Mihail Camburu, Georgiana |
author_sort | Zemba, Mihail |
collection | PubMed |
description | Uveitis-Glaucoma-Hyphaema Syndrome (UGH syndrome, or “Ellingson” Syndrome) is a rare condition caused by the mechanical trauma of an intraocular lens malpositioned over adjacent structures (iris, ciliary body, iridocorneal angle), leading to a spectrum of iris transillumination defects, microhyphaemas and pigmentary dispersion, concomitant with elevated intraocular pressure (IOP). UGH Syndrome can also be characterized by chronic inflammation, secondary iris neovascularization, cystoid macular edema (CME). The fundamental step in the pathogenesis of UGH syndrome appears to arise from repetitive mechanical iris trauma by a malpositioned or subluxed IOL. These patients have uncomplicated cataract implants and return for episodes of blurry vision weeks to months after surgery. This may be accompanied by pain, photophobia, erythropsia, anterior uveitis, hyphaema along with raised intraocular pressure. A careful history and examination, as well as appropriate investigations can confirm the diagnostic. Treatment options are IOL Explantation exchange, topical and systemic medication, and cyclophotocoagulation, the placement of a Capsular Tension Ring to redistribute zonular tension and Anti–vascular endothelial growth factor (anti-VEGF) Therapy. |
format | Online Article Text |
id | pubmed-5710046 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Romanian Society of Ophthalmology |
record_format | MEDLINE/PubMed |
spelling | pubmed-57100462017-12-14 Uveitis–Glaucoma–Hyphaema Syndrome. General review Zemba, Mihail Camburu, Georgiana Rom J Ophthalmol Reviews Uveitis-Glaucoma-Hyphaema Syndrome (UGH syndrome, or “Ellingson” Syndrome) is a rare condition caused by the mechanical trauma of an intraocular lens malpositioned over adjacent structures (iris, ciliary body, iridocorneal angle), leading to a spectrum of iris transillumination defects, microhyphaemas and pigmentary dispersion, concomitant with elevated intraocular pressure (IOP). UGH Syndrome can also be characterized by chronic inflammation, secondary iris neovascularization, cystoid macular edema (CME). The fundamental step in the pathogenesis of UGH syndrome appears to arise from repetitive mechanical iris trauma by a malpositioned or subluxed IOL. These patients have uncomplicated cataract implants and return for episodes of blurry vision weeks to months after surgery. This may be accompanied by pain, photophobia, erythropsia, anterior uveitis, hyphaema along with raised intraocular pressure. A careful history and examination, as well as appropriate investigations can confirm the diagnostic. Treatment options are IOL Explantation exchange, topical and systemic medication, and cyclophotocoagulation, the placement of a Capsular Tension Ring to redistribute zonular tension and Anti–vascular endothelial growth factor (anti-VEGF) Therapy. Romanian Society of Ophthalmology 2017 /pmc/articles/PMC5710046/ /pubmed/29450365 Text en ©Romanian Society of Ophthalmology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Zemba, Mihail Camburu, Georgiana Uveitis–Glaucoma–Hyphaema Syndrome. General review |
title | Uveitis–Glaucoma–Hyphaema Syndrome. General review
|
title_full | Uveitis–Glaucoma–Hyphaema Syndrome. General review
|
title_fullStr | Uveitis–Glaucoma–Hyphaema Syndrome. General review
|
title_full_unstemmed | Uveitis–Glaucoma–Hyphaema Syndrome. General review
|
title_short | Uveitis–Glaucoma–Hyphaema Syndrome. General review
|
title_sort | uveitis–glaucoma–hyphaema syndrome. general review |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710046/ https://www.ncbi.nlm.nih.gov/pubmed/29450365 |
work_keys_str_mv | AT zembamihail uveitisglaucomahyphaemasyndromegeneralreview AT camburugeorgiana uveitisglaucomahyphaemasyndromegeneralreview |