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Accuracy of diagnosis criteria in patients with suspected diagnosis of sporadic Creutzfeldt-Jakob disease and detection of 14-3-3 protein, France, 1992 to 2009

Diagnostic criteria of Creutzfeldt–Jakob disease (CJD), a rare and fatal transmissible nervous system disease with public health implications, are determined by clinical data, electroencephalogram (EEG), detection of 14-3-3 protein in cerebrospinal fluid (CSF), brain magnetic resonance imaging and p...

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Autores principales: Peckeu, Laurene, Delasnerie-Lauprètre, Nicole, Brandel, Jean-Philippe, Salomon, Dominique, Sazdovitch, Véronique, Laplanche, Jean-Louis, Duyckaerts, Charles, Seilhean, Danielle, Haïk, Stéphane, Hauw, Jean-Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710122/
https://www.ncbi.nlm.nih.gov/pubmed/29043964
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.41.16-00715
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author Peckeu, Laurene
Delasnerie-Lauprètre, Nicole
Brandel, Jean-Philippe
Salomon, Dominique
Sazdovitch, Véronique
Laplanche, Jean-Louis
Duyckaerts, Charles
Seilhean, Danielle
Haïk, Stéphane
Hauw, Jean-Jacques
author_facet Peckeu, Laurene
Delasnerie-Lauprètre, Nicole
Brandel, Jean-Philippe
Salomon, Dominique
Sazdovitch, Véronique
Laplanche, Jean-Louis
Duyckaerts, Charles
Seilhean, Danielle
Haïk, Stéphane
Hauw, Jean-Jacques
author_sort Peckeu, Laurene
collection PubMed
description Diagnostic criteria of Creutzfeldt–Jakob disease (CJD), a rare and fatal transmissible nervous system disease with public health implications, are determined by clinical data, electroencephalogram (EEG), detection of 14-3-3 protein in cerebrospinal fluid (CSF), brain magnetic resonance imaging and prion protein gene examination. The specificity of protein 14-3-3 has been questioned. We reviewed data from 1,572 autopsied patients collected over an 18-year period (1992–2009) and assessed whether and how 14-3-3 detection impacted the diagnosis of sporadic CJD in France, and whether this led to the misdiagnosis of treatable disorders. 14-3-3 detection was introduced into diagnostic criteria for CJD in 1998. Diagnostic accuracy decreased from 92% for the 1992–1997 period to 85% for the 1998–2009 period. This was associated with positive detections of 14-3-3 in cases with negative EEG and alternative diagnosis at autopsy. Potentially treatable diseases were found in 163 patients (10.5%). This study confirms the usefulness of the recent modification of diagnosis criteria by the addition of the results of CSF real-time quaking-induced conversion, a method based on prion seed-induced misfolding and aggregation of recombinant prion protein substrate that has proven to be a highly specific test for diagnosis of sporadic CJD.
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spelling pubmed-57101222017-12-08 Accuracy of diagnosis criteria in patients with suspected diagnosis of sporadic Creutzfeldt-Jakob disease and detection of 14-3-3 protein, France, 1992 to 2009 Peckeu, Laurene Delasnerie-Lauprètre, Nicole Brandel, Jean-Philippe Salomon, Dominique Sazdovitch, Véronique Laplanche, Jean-Louis Duyckaerts, Charles Seilhean, Danielle Haïk, Stéphane Hauw, Jean-Jacques Euro Surveill Surveillance and Outbreak Report Diagnostic criteria of Creutzfeldt–Jakob disease (CJD), a rare and fatal transmissible nervous system disease with public health implications, are determined by clinical data, electroencephalogram (EEG), detection of 14-3-3 protein in cerebrospinal fluid (CSF), brain magnetic resonance imaging and prion protein gene examination. The specificity of protein 14-3-3 has been questioned. We reviewed data from 1,572 autopsied patients collected over an 18-year period (1992–2009) and assessed whether and how 14-3-3 detection impacted the diagnosis of sporadic CJD in France, and whether this led to the misdiagnosis of treatable disorders. 14-3-3 detection was introduced into diagnostic criteria for CJD in 1998. Diagnostic accuracy decreased from 92% for the 1992–1997 period to 85% for the 1998–2009 period. This was associated with positive detections of 14-3-3 in cases with negative EEG and alternative diagnosis at autopsy. Potentially treatable diseases were found in 163 patients (10.5%). This study confirms the usefulness of the recent modification of diagnosis criteria by the addition of the results of CSF real-time quaking-induced conversion, a method based on prion seed-induced misfolding and aggregation of recombinant prion protein substrate that has proven to be a highly specific test for diagnosis of sporadic CJD. European Centre for Disease Prevention and Control (ECDC) 2017-10-12 /pmc/articles/PMC5710122/ /pubmed/29043964 http://dx.doi.org/10.2807/1560-7917.ES.2017.22.41.16-00715 Text en This article is copyright of The Authors, 2017. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Surveillance and Outbreak Report
Peckeu, Laurene
Delasnerie-Lauprètre, Nicole
Brandel, Jean-Philippe
Salomon, Dominique
Sazdovitch, Véronique
Laplanche, Jean-Louis
Duyckaerts, Charles
Seilhean, Danielle
Haïk, Stéphane
Hauw, Jean-Jacques
Accuracy of diagnosis criteria in patients with suspected diagnosis of sporadic Creutzfeldt-Jakob disease and detection of 14-3-3 protein, France, 1992 to 2009
title Accuracy of diagnosis criteria in patients with suspected diagnosis of sporadic Creutzfeldt-Jakob disease and detection of 14-3-3 protein, France, 1992 to 2009
title_full Accuracy of diagnosis criteria in patients with suspected diagnosis of sporadic Creutzfeldt-Jakob disease and detection of 14-3-3 protein, France, 1992 to 2009
title_fullStr Accuracy of diagnosis criteria in patients with suspected diagnosis of sporadic Creutzfeldt-Jakob disease and detection of 14-3-3 protein, France, 1992 to 2009
title_full_unstemmed Accuracy of diagnosis criteria in patients with suspected diagnosis of sporadic Creutzfeldt-Jakob disease and detection of 14-3-3 protein, France, 1992 to 2009
title_short Accuracy of diagnosis criteria in patients with suspected diagnosis of sporadic Creutzfeldt-Jakob disease and detection of 14-3-3 protein, France, 1992 to 2009
title_sort accuracy of diagnosis criteria in patients with suspected diagnosis of sporadic creutzfeldt-jakob disease and detection of 14-3-3 protein, france, 1992 to 2009
topic Surveillance and Outbreak Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710122/
https://www.ncbi.nlm.nih.gov/pubmed/29043964
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.41.16-00715
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