Genomic imprinting of Xist by maternal H3K27me3

Maternal imprinting at the Xist gene is essential to achieve paternal allele-specific imprinted X-chromosome inactivation (XCI) in female mammals. However, the mechanism underlying Xist imprinting is unclear. Here we show that the Xist locus is coated with a broad H3K27me3 domain that is established...

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Detalles Bibliográficos
Autores principales: Inoue, Azusa, Jiang, Lan, Lu, Falong, Zhang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710138/
https://www.ncbi.nlm.nih.gov/pubmed/29089420
http://dx.doi.org/10.1101/gad.304113.117
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author Inoue, Azusa
Jiang, Lan
Lu, Falong
Zhang, Yi
author_facet Inoue, Azusa
Jiang, Lan
Lu, Falong
Zhang, Yi
author_sort Inoue, Azusa
collection PubMed
description Maternal imprinting at the Xist gene is essential to achieve paternal allele-specific imprinted X-chromosome inactivation (XCI) in female mammals. However, the mechanism underlying Xist imprinting is unclear. Here we show that the Xist locus is coated with a broad H3K27me3 domain that is established during oocyte growth and persists through preimplantation development in mice. Loss of maternal H3K27me3 induces maternal Xist expression and maternal XCI in preimplantation embryos. Our study thus identifies maternal H3K27me3 as the imprinting mark of Xist.
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spelling pubmed-57101382018-04-01 Genomic imprinting of Xist by maternal H3K27me3 Inoue, Azusa Jiang, Lan Lu, Falong Zhang, Yi Genes Dev Research Communication Maternal imprinting at the Xist gene is essential to achieve paternal allele-specific imprinted X-chromosome inactivation (XCI) in female mammals. However, the mechanism underlying Xist imprinting is unclear. Here we show that the Xist locus is coated with a broad H3K27me3 domain that is established during oocyte growth and persists through preimplantation development in mice. Loss of maternal H3K27me3 induces maternal Xist expression and maternal XCI in preimplantation embryos. Our study thus identifies maternal H3K27me3 as the imprinting mark of Xist. Cold Spring Harbor Laboratory Press 2017-10-01 /pmc/articles/PMC5710138/ /pubmed/29089420 http://dx.doi.org/10.1101/gad.304113.117 Text en © 2017 Inoue et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Research Communication
Inoue, Azusa
Jiang, Lan
Lu, Falong
Zhang, Yi
Genomic imprinting of Xist by maternal H3K27me3
title Genomic imprinting of Xist by maternal H3K27me3
title_full Genomic imprinting of Xist by maternal H3K27me3
title_fullStr Genomic imprinting of Xist by maternal H3K27me3
title_full_unstemmed Genomic imprinting of Xist by maternal H3K27me3
title_short Genomic imprinting of Xist by maternal H3K27me3
title_sort genomic imprinting of xist by maternal h3k27me3
topic Research Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710138/
https://www.ncbi.nlm.nih.gov/pubmed/29089420
http://dx.doi.org/10.1101/gad.304113.117
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