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Suppression of protein tyrosine phosphatase N23 predisposes to breast tumorigenesis via activation of FYN kinase

Disruption of the balanced modulation of reversible tyrosine phosphorylation has been implicated in the etiology of various human cancers, including breast cancer. Protein Tyrosine Phosphatase N23 (PTPN23) resides in chromosomal region 3p21.3, which is hemizygously or homozygously lost in some breas...

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Detalles Bibliográficos
Autores principales:	Zhang, Siwei, Fan, Gaofeng, Hao, Yuan, Hammell, Molly, Wilkinson, John Erby, Tonks, Nicholas K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710140/ https://www.ncbi.nlm.nih.gov/pubmed/29066500 http://dx.doi.org/10.1101/gad.304261.117

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