Inhibition of Miro1 disturbs mitophagy and pancreatic β-cell function interfering insulin release via IRS-Akt-Foxo1 in diabetes

Mitochondrial function is essential to meet metabolic demand of pancreatic beta cells respond to high nutrient stress. Mitophagy is an essential component to normal pancreatic β-cell function and has been associated with β-cell failure in Type 2 diabetes (T2D). Our previous studies have indicated th...

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Detalles Bibliográficos
Autores principales: Chen, Lingling, Liu, Chunyan, Gao, Jianfeng, Xie, Zhiwen, Chan, Lawrence W.C., Keating, Damien J., Yang, Yibin, Sun, Jiazhong, Zhou, Fuling, Wei, Yongchang, Men, Xiuli, Yang, Sijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper: Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710878/
https://www.ncbi.nlm.nih.gov/pubmed/29207597
http://dx.doi.org/10.18632/oncotarget.20963

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