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Stanniocalcin2 acts as an anorectic factor through activation of STAT3 pathway

The regulation of food intake and body weight has been hotly investigated. In the present study, we show that stanniocalcin2 (STC2), a cytokine ubiquitously expressed and especially upregulated in many types of human cancers, has a regulatory role in food intake and weight loss. Systemic treatment o...

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Autores principales: Jiao, Yang, Zhao, Jiejie, Shi, Guojun, Liu, Xing, Xiong, Xuelian, Li, Xiaoying, Zhang, Huijie, Ma, Qinyun, Lu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710906/
https://www.ncbi.nlm.nih.gov/pubmed/29207625
http://dx.doi.org/10.18632/oncotarget.19412
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author Jiao, Yang
Zhao, Jiejie
Shi, Guojun
Liu, Xing
Xiong, Xuelian
Li, Xiaoying
Zhang, Huijie
Ma, Qinyun
Lu, Yan
author_facet Jiao, Yang
Zhao, Jiejie
Shi, Guojun
Liu, Xing
Xiong, Xuelian
Li, Xiaoying
Zhang, Huijie
Ma, Qinyun
Lu, Yan
author_sort Jiao, Yang
collection PubMed
description The regulation of food intake and body weight has been hotly investigated. In the present study, we show that stanniocalcin2 (STC2), a cytokine ubiquitously expressed and especially upregulated in many types of human cancers, has a regulatory role in food intake and weight loss. Systemic treatment of C57BL/6 mice with recombinant STC2 protein resulted in decreased food intake and body weight, whereas energy expenditure was not affected. Similarly, STC2 treatment also induced anorexia in hyperphagic leptin-deficient mice, leading to a significant reduction in body weight and improvement of blood glucose levels. Furthermore, intracerebroventricular administration of STC2 to mice led to an acute decrease in food intake, which was mediated, at least in part, by activation of STAT3 pathway. Taken together, our results revealed the importance of STC2 in the regulation of feeding behavior as well as body weight.
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spelling pubmed-57109062017-12-04 Stanniocalcin2 acts as an anorectic factor through activation of STAT3 pathway Jiao, Yang Zhao, Jiejie Shi, Guojun Liu, Xing Xiong, Xuelian Li, Xiaoying Zhang, Huijie Ma, Qinyun Lu, Yan Oncotarget Research Paper The regulation of food intake and body weight has been hotly investigated. In the present study, we show that stanniocalcin2 (STC2), a cytokine ubiquitously expressed and especially upregulated in many types of human cancers, has a regulatory role in food intake and weight loss. Systemic treatment of C57BL/6 mice with recombinant STC2 protein resulted in decreased food intake and body weight, whereas energy expenditure was not affected. Similarly, STC2 treatment also induced anorexia in hyperphagic leptin-deficient mice, leading to a significant reduction in body weight and improvement of blood glucose levels. Furthermore, intracerebroventricular administration of STC2 to mice led to an acute decrease in food intake, which was mediated, at least in part, by activation of STAT3 pathway. Taken together, our results revealed the importance of STC2 in the regulation of feeding behavior as well as body weight. Impact Journals LLC 2017-07-20 /pmc/articles/PMC5710906/ /pubmed/29207625 http://dx.doi.org/10.18632/oncotarget.19412 Text en Copyright: © 2017 Jiao et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Jiao, Yang
Zhao, Jiejie
Shi, Guojun
Liu, Xing
Xiong, Xuelian
Li, Xiaoying
Zhang, Huijie
Ma, Qinyun
Lu, Yan
Stanniocalcin2 acts as an anorectic factor through activation of STAT3 pathway
title Stanniocalcin2 acts as an anorectic factor through activation of STAT3 pathway
title_full Stanniocalcin2 acts as an anorectic factor through activation of STAT3 pathway
title_fullStr Stanniocalcin2 acts as an anorectic factor through activation of STAT3 pathway
title_full_unstemmed Stanniocalcin2 acts as an anorectic factor through activation of STAT3 pathway
title_short Stanniocalcin2 acts as an anorectic factor through activation of STAT3 pathway
title_sort stanniocalcin2 acts as an anorectic factor through activation of stat3 pathway
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710906/
https://www.ncbi.nlm.nih.gov/pubmed/29207625
http://dx.doi.org/10.18632/oncotarget.19412
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