Cargando…
Stanniocalcin2 acts as an anorectic factor through activation of STAT3 pathway
The regulation of food intake and body weight has been hotly investigated. In the present study, we show that stanniocalcin2 (STC2), a cytokine ubiquitously expressed and especially upregulated in many types of human cancers, has a regulatory role in food intake and weight loss. Systemic treatment o...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710906/ https://www.ncbi.nlm.nih.gov/pubmed/29207625 http://dx.doi.org/10.18632/oncotarget.19412 |
_version_ | 1783282965658206208 |
---|---|
author | Jiao, Yang Zhao, Jiejie Shi, Guojun Liu, Xing Xiong, Xuelian Li, Xiaoying Zhang, Huijie Ma, Qinyun Lu, Yan |
author_facet | Jiao, Yang Zhao, Jiejie Shi, Guojun Liu, Xing Xiong, Xuelian Li, Xiaoying Zhang, Huijie Ma, Qinyun Lu, Yan |
author_sort | Jiao, Yang |
collection | PubMed |
description | The regulation of food intake and body weight has been hotly investigated. In the present study, we show that stanniocalcin2 (STC2), a cytokine ubiquitously expressed and especially upregulated in many types of human cancers, has a regulatory role in food intake and weight loss. Systemic treatment of C57BL/6 mice with recombinant STC2 protein resulted in decreased food intake and body weight, whereas energy expenditure was not affected. Similarly, STC2 treatment also induced anorexia in hyperphagic leptin-deficient mice, leading to a significant reduction in body weight and improvement of blood glucose levels. Furthermore, intracerebroventricular administration of STC2 to mice led to an acute decrease in food intake, which was mediated, at least in part, by activation of STAT3 pathway. Taken together, our results revealed the importance of STC2 in the regulation of feeding behavior as well as body weight. |
format | Online Article Text |
id | pubmed-5710906 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-57109062017-12-04 Stanniocalcin2 acts as an anorectic factor through activation of STAT3 pathway Jiao, Yang Zhao, Jiejie Shi, Guojun Liu, Xing Xiong, Xuelian Li, Xiaoying Zhang, Huijie Ma, Qinyun Lu, Yan Oncotarget Research Paper The regulation of food intake and body weight has been hotly investigated. In the present study, we show that stanniocalcin2 (STC2), a cytokine ubiquitously expressed and especially upregulated in many types of human cancers, has a regulatory role in food intake and weight loss. Systemic treatment of C57BL/6 mice with recombinant STC2 protein resulted in decreased food intake and body weight, whereas energy expenditure was not affected. Similarly, STC2 treatment also induced anorexia in hyperphagic leptin-deficient mice, leading to a significant reduction in body weight and improvement of blood glucose levels. Furthermore, intracerebroventricular administration of STC2 to mice led to an acute decrease in food intake, which was mediated, at least in part, by activation of STAT3 pathway. Taken together, our results revealed the importance of STC2 in the regulation of feeding behavior as well as body weight. Impact Journals LLC 2017-07-20 /pmc/articles/PMC5710906/ /pubmed/29207625 http://dx.doi.org/10.18632/oncotarget.19412 Text en Copyright: © 2017 Jiao et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Jiao, Yang Zhao, Jiejie Shi, Guojun Liu, Xing Xiong, Xuelian Li, Xiaoying Zhang, Huijie Ma, Qinyun Lu, Yan Stanniocalcin2 acts as an anorectic factor through activation of STAT3 pathway |
title | Stanniocalcin2 acts as an anorectic factor through activation of STAT3 pathway |
title_full | Stanniocalcin2 acts as an anorectic factor through activation of STAT3 pathway |
title_fullStr | Stanniocalcin2 acts as an anorectic factor through activation of STAT3 pathway |
title_full_unstemmed | Stanniocalcin2 acts as an anorectic factor through activation of STAT3 pathway |
title_short | Stanniocalcin2 acts as an anorectic factor through activation of STAT3 pathway |
title_sort | stanniocalcin2 acts as an anorectic factor through activation of stat3 pathway |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710906/ https://www.ncbi.nlm.nih.gov/pubmed/29207625 http://dx.doi.org/10.18632/oncotarget.19412 |
work_keys_str_mv | AT jiaoyang stanniocalcin2actsasananorecticfactorthroughactivationofstat3pathway AT zhaojiejie stanniocalcin2actsasananorecticfactorthroughactivationofstat3pathway AT shiguojun stanniocalcin2actsasananorecticfactorthroughactivationofstat3pathway AT liuxing stanniocalcin2actsasananorecticfactorthroughactivationofstat3pathway AT xiongxuelian stanniocalcin2actsasananorecticfactorthroughactivationofstat3pathway AT lixiaoying stanniocalcin2actsasananorecticfactorthroughactivationofstat3pathway AT zhanghuijie stanniocalcin2actsasananorecticfactorthroughactivationofstat3pathway AT maqinyun stanniocalcin2actsasananorecticfactorthroughactivationofstat3pathway AT luyan stanniocalcin2actsasananorecticfactorthroughactivationofstat3pathway |