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Sigma-1 and Sigma-2 receptor ligands induce apoptosis and autophagy but have opposite effect on cell proliferation in uveal melanoma
Uveal melanoma is the most common primary intraocular tumor in adults, with about 1200–1500 new cases occurring per year in the United States. Metastasis is a frequent occurrence in uveal melanoma, and outcomes are poor once distant spread occurs and no clinically significant chemotherapeutic protoc...
Autores principales: | Longhitano, Lucia, Castracani, Carlo Castruccio, Tibullo, Daniele, Avola, Roberto, Viola, Maria, Russo, Giuliano, Prezzavento, Orazio, Marrazzo, Agostino, Amata, Emanuele, Reibaldi, Michele, Longo, Antonio, Russo, Andrea, Parrinello, Nunziatina Laura, Volti, Giovanni Li |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710909/ https://www.ncbi.nlm.nih.gov/pubmed/29207628 http://dx.doi.org/10.18632/oncotarget.19556 |
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