Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons

Amyotrophic lateral sclerosis (ALS) is the most common adult-onset neuromuscular disorder characterised by selective loss of motor neurons leading to fatal paralysis. Current therapeutic approaches are limited in their effectiveness. Substantial advances in understanding ALS disease mechanisms has c...

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Detalles Bibliográficos
Autores principales: Kondori, Nazanin Rahmani, Paul, Praveen, Robbins, Jacqueline P., Liu, Ke, Hildyard, John C. W., Wells, Dominic J., de Belleroche, Jacqueline S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711026/
https://www.ncbi.nlm.nih.gov/pubmed/29194436
http://dx.doi.org/10.1371/journal.pone.0188912

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