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An anthropomorphic spine phantom for proton beam approval in NCI‐funded trials

As part of the approval process for the use of scattered or uniform scanning proton therapy in National Cancer Institute (NCI)‐sponsored clinical trials, the Radiological Physics Center (RPC) mandates irradiation of two RPC anthropomorphic proton phantoms (prostate and spine). The RPC evaluates thes...

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Autores principales: Cho, Jongmin, Summers, Paige A., Ibbott, Geoffrey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711048/
https://www.ncbi.nlm.nih.gov/pubmed/24892351
http://dx.doi.org/10.1120/jacmp.v15i3.4742
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author Cho, Jongmin
Summers, Paige A.
Ibbott, Geoffrey S.
author_facet Cho, Jongmin
Summers, Paige A.
Ibbott, Geoffrey S.
author_sort Cho, Jongmin
collection PubMed
description As part of the approval process for the use of scattered or uniform scanning proton therapy in National Cancer Institute (NCI)‐sponsored clinical trials, the Radiological Physics Center (RPC) mandates irradiation of two RPC anthropomorphic proton phantoms (prostate and spine). The RPC evaluates these irradiations to ensure that they agree with the institutions' treatment plans within criteria of the NCI‐funded cooperative study groups. The purpose of this study was to evaluate the use of an anthropomorphic spine phantom for proton matched‐field irradiation, and to assess its use as a credentialing tool for proton therapy beams. We used an anthropomorphic spine phantom made of human vertebral bodies embedded in a tissue substitute material called Muscle Substitute/Solid Rigid Number 4 (MS/SR4) comprising three sections: a posterior section containing the posterior surface and the spinous processes, and left and right (L/R) sections containing the vertebral bodies and the transverse processes. After feasibility studies at three institutions, the phantom, containing two thermoluminescent dosimeters (TLDs) for absolute dose measurements and two sheets of radiochromic film for relative dosimetry, was shipped consecutively to eight proton therapy centers participating in the approval study. At each center, the phantom was placed in a supine or prone position (according to the institution's spine treatment protocol) and imaged with computed tomography (CT). The images then were used with the institution's treatment planning system (TPS) to generate two matched fields, and the phantom was irradiated accordingly. The irradiated phantom was shipped to the RPC for analysis, and the measured values were compared with the institution's TPS dose and profiles using criteria of ± 7% for dose agreement and 5 mm for profile distance to agreement. All proton centers passed the dose criterion with a mean agreement of 3% (maximum observed agreement, 7%). One center failed the profile distance‐to‐agreement criterion on its initial irradiation, but its second irradiation passed the criterion. Another center failed the profile distance‐to‐agreement criterion, but no repeat irradiation was performed. Thus, seven of the eight institutions passed the film profile distance‐to‐agreement criterion with a mean agreement of 1.2 mm (maximum observed agreement 5 mm). We conclude that an anthropomorphic spine phantom using TLD and radiochromic film adequately verified dose delivery and field placement for matched‐field treatments. PACS number: 87.55.‐x, 87.55.N‐
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spelling pubmed-57110482018-04-02 An anthropomorphic spine phantom for proton beam approval in NCI‐funded trials Cho, Jongmin Summers, Paige A. Ibbott, Geoffrey S. J Appl Clin Med Phys Radiation Oncology Physics As part of the approval process for the use of scattered or uniform scanning proton therapy in National Cancer Institute (NCI)‐sponsored clinical trials, the Radiological Physics Center (RPC) mandates irradiation of two RPC anthropomorphic proton phantoms (prostate and spine). The RPC evaluates these irradiations to ensure that they agree with the institutions' treatment plans within criteria of the NCI‐funded cooperative study groups. The purpose of this study was to evaluate the use of an anthropomorphic spine phantom for proton matched‐field irradiation, and to assess its use as a credentialing tool for proton therapy beams. We used an anthropomorphic spine phantom made of human vertebral bodies embedded in a tissue substitute material called Muscle Substitute/Solid Rigid Number 4 (MS/SR4) comprising three sections: a posterior section containing the posterior surface and the spinous processes, and left and right (L/R) sections containing the vertebral bodies and the transverse processes. After feasibility studies at three institutions, the phantom, containing two thermoluminescent dosimeters (TLDs) for absolute dose measurements and two sheets of radiochromic film for relative dosimetry, was shipped consecutively to eight proton therapy centers participating in the approval study. At each center, the phantom was placed in a supine or prone position (according to the institution's spine treatment protocol) and imaged with computed tomography (CT). The images then were used with the institution's treatment planning system (TPS) to generate two matched fields, and the phantom was irradiated accordingly. The irradiated phantom was shipped to the RPC for analysis, and the measured values were compared with the institution's TPS dose and profiles using criteria of ± 7% for dose agreement and 5 mm for profile distance to agreement. All proton centers passed the dose criterion with a mean agreement of 3% (maximum observed agreement, 7%). One center failed the profile distance‐to‐agreement criterion on its initial irradiation, but its second irradiation passed the criterion. Another center failed the profile distance‐to‐agreement criterion, but no repeat irradiation was performed. Thus, seven of the eight institutions passed the film profile distance‐to‐agreement criterion with a mean agreement of 1.2 mm (maximum observed agreement 5 mm). We conclude that an anthropomorphic spine phantom using TLD and radiochromic film adequately verified dose delivery and field placement for matched‐field treatments. PACS number: 87.55.‐x, 87.55.N‐ John Wiley and Sons Inc. 2014-05-08 /pmc/articles/PMC5711048/ /pubmed/24892351 http://dx.doi.org/10.1120/jacmp.v15i3.4742 Text en © 2014 The Authors. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Cho, Jongmin
Summers, Paige A.
Ibbott, Geoffrey S.
An anthropomorphic spine phantom for proton beam approval in NCI‐funded trials
title An anthropomorphic spine phantom for proton beam approval in NCI‐funded trials
title_full An anthropomorphic spine phantom for proton beam approval in NCI‐funded trials
title_fullStr An anthropomorphic spine phantom for proton beam approval in NCI‐funded trials
title_full_unstemmed An anthropomorphic spine phantom for proton beam approval in NCI‐funded trials
title_short An anthropomorphic spine phantom for proton beam approval in NCI‐funded trials
title_sort anthropomorphic spine phantom for proton beam approval in nci‐funded trials
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711048/
https://www.ncbi.nlm.nih.gov/pubmed/24892351
http://dx.doi.org/10.1120/jacmp.v15i3.4742
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