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Four‐and‐one‐half years' experience in monitoring of reproducibility of an MR spectroscopy system — application of in vitro results to interpretation of in vivo data
The primary purpose of this work was to assess long‐term in vitro reproducibility of metabolite levels measured using (1)H MRS (proton magnetic resonance spectroscopy). The secondary purpose was to use the in vitro results for interpretation of ‘H MRS in vivo spectra acquired from patients diagnosed...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711050/ https://www.ncbi.nlm.nih.gov/pubmed/24892353 http://dx.doi.org/10.1120/jacmp.v15i3.4754 |
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author | Skorupa, Agnieszka Wicher, Magdalena Banasik, Tomasz Jamroz, Ewa Paprocka, Justyna Kiettyka, Aleksandra Sokót, Maria Konopka, Marek |
author_facet | Skorupa, Agnieszka Wicher, Magdalena Banasik, Tomasz Jamroz, Ewa Paprocka, Justyna Kiettyka, Aleksandra Sokót, Maria Konopka, Marek |
author_sort | Skorupa, Agnieszka |
collection | PubMed |
description | The primary purpose of this work was to assess long‐term in vitro reproducibility of metabolite levels measured using (1)H MRS (proton magnetic resonance spectroscopy). The secondary purpose was to use the in vitro results for interpretation of ‘H MRS in vivo spectra acquired from patients diagnosed with Canavan disease. (1)H MRS measurements were performed in the period from April 2006 to September 2010. 118 short and 116 long echo spectra were acquired from a stable phantom during this period. Change‐point analysis of the in vitro N‐acetylaspartate levels was exploited in the computation of f(T) factor (ratio of the actual to the reference N‐acetylaspartate level normalized by the reciprocity principle). This coefficient was utilized in the interpretation of in vivo spectra analyzed using absolute reference technique. The monitored time period was divided into six time intervals based on short echo in vitro data (seven time intervals based on long echo in vitro data) characterized by f(T) coefficient ranging from 0.97 to 1.09 (based on short echo data) and from 1.0 to 1.11 (based on long echo data). Application of this coefficient to interpretation of in vivo spectra confirmed increased N‐acetylaspartate level in Canavan disease. Long‐term monitoring of an MRS system reproducibility, allowing for absolute referencing of metabolite levels, facilitates interpretation of metabolic changes in white matter disorders. PACS numbers: 87.19.lf, 87.61.Tg, 87.64.K‐, 87.64.kj |
format | Online Article Text |
id | pubmed-5711050 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-57110502018-04-02 Four‐and‐one‐half years' experience in monitoring of reproducibility of an MR spectroscopy system — application of in vitro results to interpretation of in vivo data Skorupa, Agnieszka Wicher, Magdalena Banasik, Tomasz Jamroz, Ewa Paprocka, Justyna Kiettyka, Aleksandra Sokót, Maria Konopka, Marek J Appl Clin Med Phys Non‐ionizing Topics The primary purpose of this work was to assess long‐term in vitro reproducibility of metabolite levels measured using (1)H MRS (proton magnetic resonance spectroscopy). The secondary purpose was to use the in vitro results for interpretation of ‘H MRS in vivo spectra acquired from patients diagnosed with Canavan disease. (1)H MRS measurements were performed in the period from April 2006 to September 2010. 118 short and 116 long echo spectra were acquired from a stable phantom during this period. Change‐point analysis of the in vitro N‐acetylaspartate levels was exploited in the computation of f(T) factor (ratio of the actual to the reference N‐acetylaspartate level normalized by the reciprocity principle). This coefficient was utilized in the interpretation of in vivo spectra analyzed using absolute reference technique. The monitored time period was divided into six time intervals based on short echo in vitro data (seven time intervals based on long echo in vitro data) characterized by f(T) coefficient ranging from 0.97 to 1.09 (based on short echo data) and from 1.0 to 1.11 (based on long echo data). Application of this coefficient to interpretation of in vivo spectra confirmed increased N‐acetylaspartate level in Canavan disease. Long‐term monitoring of an MRS system reproducibility, allowing for absolute referencing of metabolite levels, facilitates interpretation of metabolic changes in white matter disorders. PACS numbers: 87.19.lf, 87.61.Tg, 87.64.K‐, 87.64.kj John Wiley and Sons Inc. 2014-05-08 /pmc/articles/PMC5711050/ /pubmed/24892353 http://dx.doi.org/10.1120/jacmp.v15i3.4754 Text en © 2014 The Authors. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Non‐ionizing Topics Skorupa, Agnieszka Wicher, Magdalena Banasik, Tomasz Jamroz, Ewa Paprocka, Justyna Kiettyka, Aleksandra Sokót, Maria Konopka, Marek Four‐and‐one‐half years' experience in monitoring of reproducibility of an MR spectroscopy system — application of in vitro results to interpretation of in vivo data |
title | Four‐and‐one‐half years' experience in monitoring of reproducibility of an MR spectroscopy system — application of in vitro results to interpretation of in vivo data |
title_full | Four‐and‐one‐half years' experience in monitoring of reproducibility of an MR spectroscopy system — application of in vitro results to interpretation of in vivo data |
title_fullStr | Four‐and‐one‐half years' experience in monitoring of reproducibility of an MR spectroscopy system — application of in vitro results to interpretation of in vivo data |
title_full_unstemmed | Four‐and‐one‐half years' experience in monitoring of reproducibility of an MR spectroscopy system — application of in vitro results to interpretation of in vivo data |
title_short | Four‐and‐one‐half years' experience in monitoring of reproducibility of an MR spectroscopy system — application of in vitro results to interpretation of in vivo data |
title_sort | four‐and‐one‐half years' experience in monitoring of reproducibility of an mr spectroscopy system — application of in vitro results to interpretation of in vivo data |
topic | Non‐ionizing Topics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711050/ https://www.ncbi.nlm.nih.gov/pubmed/24892353 http://dx.doi.org/10.1120/jacmp.v15i3.4754 |
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