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Performance evaluation of a newly developed high‐resolution, dual‐head animal SPECT system based on the NEMA NU1–2007 standard

Small‐animal single‐photon emission computed tomography (SPECT) system plays an important role in the field of drug development and investigation of potential drugs in the preclinical phase. The small‐animal High‐Resolution SPECT (HiReSPECT) scanner has been recently designed and developed based on...

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Autores principales: Moji, Vahideh, Zeraatkar, Navid, Farahani, Mohammad Hossein, Aghamiri, Mahmood Reza, Sajedi, Salar, Teimourian, Behnoosh, Ghafarian, Pardis, Sarkar, Saeed, Ay, Mohammad Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711132/
https://www.ncbi.nlm.nih.gov/pubmed/25493518
http://dx.doi.org/10.1120/jacmp.v15i6.4936
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author Moji, Vahideh
Zeraatkar, Navid
Farahani, Mohammad Hossein
Aghamiri, Mahmood Reza
Sajedi, Salar
Teimourian, Behnoosh
Ghafarian, Pardis
Sarkar, Saeed
Ay, Mohammad Reza
author_facet Moji, Vahideh
Zeraatkar, Navid
Farahani, Mohammad Hossein
Aghamiri, Mahmood Reza
Sajedi, Salar
Teimourian, Behnoosh
Ghafarian, Pardis
Sarkar, Saeed
Ay, Mohammad Reza
author_sort Moji, Vahideh
collection PubMed
description Small‐animal single‐photon emission computed tomography (SPECT) system plays an important role in the field of drug development and investigation of potential drugs in the preclinical phase. The small‐animal High‐Resolution SPECT (HiReSPECT) scanner has been recently designed and developed based on compact and high‐resolution detectors. The detectors are based on a high‐resolution parallel hole collimator, a cesium iodide (sodium‐activated) pixelated crystal array and two H8500 position‐sensitive photomultiplier tubes. In this system, a full set of data corrections such as energy, linearity, and uniformity, together with resolution recovery option in reconstruction algorithms, are available. In this study, we assessed the performance of the system based on NEMA‐NU1–2007 standards for pixelated detector cameras. Characterization of the HiReSPECT was performed by measurement of the physical parameters including planar and tomographic performance. The planar performance of the system was characterized with flood‐field phantom for energy resolution and uniformity. Spatial resolution and sensitivity were evaluated as functions of distance with capillary tube and cylindrical source, respectively. Tomographic spatial resolution was characterized as a function of radius of rotation (ROR). A dedicated hot rod phantom and image quality phantom was used for the evaluation of overall tomographic quality of the HiReSPECT. The results showed that the planar spatial resolution was [Formula: see text] and [Formula: see text] in terms of full‐width at half‐maximum (FWHM) along short‐ and long‐axis dimensions, respectively, when the source was placed on the detector surface. The integral uniformity of the system after uniformity correction was 1.7% and 1.2% in useful field of view (UFOV) and central field of view (CFOV), respectively. System sensitivity on the collimator surface was [Formula: see text] and didn't vary significantly with distance. Mean tomographic spatial resolution was measured [Formula: see text] mm FWHM at the radius of rotation of 25 mm with dual‐head configuration. The measured performance demonstrated that the HiReSPECT scanner has acceptable image quality and, hence, is well suited for preclinical molecular imaging research. PACS number: 87.57.U
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spelling pubmed-57111322018-04-02 Performance evaluation of a newly developed high‐resolution, dual‐head animal SPECT system based on the NEMA NU1–2007 standard Moji, Vahideh Zeraatkar, Navid Farahani, Mohammad Hossein Aghamiri, Mahmood Reza Sajedi, Salar Teimourian, Behnoosh Ghafarian, Pardis Sarkar, Saeed Ay, Mohammad Reza J Appl Clin Med Phys Medical Imaging Small‐animal single‐photon emission computed tomography (SPECT) system plays an important role in the field of drug development and investigation of potential drugs in the preclinical phase. The small‐animal High‐Resolution SPECT (HiReSPECT) scanner has been recently designed and developed based on compact and high‐resolution detectors. The detectors are based on a high‐resolution parallel hole collimator, a cesium iodide (sodium‐activated) pixelated crystal array and two H8500 position‐sensitive photomultiplier tubes. In this system, a full set of data corrections such as energy, linearity, and uniformity, together with resolution recovery option in reconstruction algorithms, are available. In this study, we assessed the performance of the system based on NEMA‐NU1–2007 standards for pixelated detector cameras. Characterization of the HiReSPECT was performed by measurement of the physical parameters including planar and tomographic performance. The planar performance of the system was characterized with flood‐field phantom for energy resolution and uniformity. Spatial resolution and sensitivity were evaluated as functions of distance with capillary tube and cylindrical source, respectively. Tomographic spatial resolution was characterized as a function of radius of rotation (ROR). A dedicated hot rod phantom and image quality phantom was used for the evaluation of overall tomographic quality of the HiReSPECT. The results showed that the planar spatial resolution was [Formula: see text] and [Formula: see text] in terms of full‐width at half‐maximum (FWHM) along short‐ and long‐axis dimensions, respectively, when the source was placed on the detector surface. The integral uniformity of the system after uniformity correction was 1.7% and 1.2% in useful field of view (UFOV) and central field of view (CFOV), respectively. System sensitivity on the collimator surface was [Formula: see text] and didn't vary significantly with distance. Mean tomographic spatial resolution was measured [Formula: see text] mm FWHM at the radius of rotation of 25 mm with dual‐head configuration. The measured performance demonstrated that the HiReSPECT scanner has acceptable image quality and, hence, is well suited for preclinical molecular imaging research. PACS number: 87.57.U John Wiley and Sons Inc. 2014-11-08 /pmc/articles/PMC5711132/ /pubmed/25493518 http://dx.doi.org/10.1120/jacmp.v15i6.4936 Text en © 2014 The Authors. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Medical Imaging
Moji, Vahideh
Zeraatkar, Navid
Farahani, Mohammad Hossein
Aghamiri, Mahmood Reza
Sajedi, Salar
Teimourian, Behnoosh
Ghafarian, Pardis
Sarkar, Saeed
Ay, Mohammad Reza
Performance evaluation of a newly developed high‐resolution, dual‐head animal SPECT system based on the NEMA NU1–2007 standard
title Performance evaluation of a newly developed high‐resolution, dual‐head animal SPECT system based on the NEMA NU1–2007 standard
title_full Performance evaluation of a newly developed high‐resolution, dual‐head animal SPECT system based on the NEMA NU1–2007 standard
title_fullStr Performance evaluation of a newly developed high‐resolution, dual‐head animal SPECT system based on the NEMA NU1–2007 standard
title_full_unstemmed Performance evaluation of a newly developed high‐resolution, dual‐head animal SPECT system based on the NEMA NU1–2007 standard
title_short Performance evaluation of a newly developed high‐resolution, dual‐head animal SPECT system based on the NEMA NU1–2007 standard
title_sort performance evaluation of a newly developed high‐resolution, dual‐head animal spect system based on the nema nu1–2007 standard
topic Medical Imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711132/
https://www.ncbi.nlm.nih.gov/pubmed/25493518
http://dx.doi.org/10.1120/jacmp.v15i6.4936
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